Amyloidosis affects millions of people, as a cause of Alzheimer's disease or a complication
of dialysis, and also causes rare conditions. The many forms of the disorder have one …

Recent evidence indicates that diverse neurodegenerative diseases might have a common
cause and pathological mechanism—the misfolding, aggregation and accumulation of …

Cardiac amyloidosis is a serious and progressive infiltrative disease that is caused by the
deposition of amyloid fibrils at the cardiac level. It can be due to rare genetic variants in the …

Cardiac amyloidosis is a serious and progressive infiltrative disease that is caused by the
deposition of amyloid fibrils at the cardiac level. It can be due to rare genetic variants in the …

Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding
aggregates. Substantial data support the hypothesis that partially folded intermediates are …

Objectives: To evaluate the efficacy and safety of 18 months of tafamidis treatment in
patients with early-stage V30M transthyretin familial amyloid polyneuropathy (TTR-FAP) …

Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-
mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila …

The conformational change hypothesis postulates that tertiary structural changes under
partially denaturing conditions convert one of 17 normally soluble and functional human …

The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …

Publisher Summary The chapter discusses the structural analysis of amyloid fibrils by
electron microscopy and X-ray diffraction. A method to isolate amyloid fibrils from tissue was …