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Mechanistic insights into precursor messenger RNA splicing by the spliceosome
Y Shi - Nature reviews Molecular cell biology, 2017 - nature.com
Precursor messenger RNA (pre-mRNA) splicing is an essential step in the flow of
information from DNA to protein in all eukaryotes. Research over the past four decades has …
information from DNA to protein in all eukaryotes. Research over the past four decades has …
[HTML][HTML] Mechanical devices of the spliceosome: motors, clocks, springs, and things
JP Staley, C Guthrie - Cell, 1998 - cell.com
The discovery of interrupted genes and messenger RNA (mRNA) splicing 20 years ago was
greeted with amazement (Berget et al. 1977; Chow et al. 1977). Although introns needed to …
greeted with amazement (Berget et al. 1977; Chow et al. 1977). Although introns needed to …
RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites
Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to
achieve their diverse functions. To identify these contacts, we developed a method based on …
achieve their diverse functions. To identify these contacts, we developed a method based on …
The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: causes and consequences
M Krawczak, J Reiss, DN Cooper - Human genetics, 1992 - Springer
A total of 101 different examples of point mutations, which lie in the vicinity of mRNA splice
junctions, and which have been held to be responsible for a human genetic disease by …
junctions, and which have been held to be responsible for a human genetic disease by …
Prediction of human mRNA donor and acceptor sites from the DNA sequence
Artificial neural networks have been applied to the prediction of splice site location in human
pre-mRNA. A joint prediction scheme where prediction of transition regions between introns …
pre-mRNA. A joint prediction scheme where prediction of transition regions between introns …
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
DA Melton, PA Krieg, MR Rebagliati… - Nucleic acids …, 1984 - academic.oup.com
A simple and efficient method for synthesizing pure single stranded RNAs of virtually any
structure is described. This in vitro transcription system is based on the unusually specific …
structure is described. This in vitro transcription system is based on the unusually specific …
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
The removal of intervening sequences from transcripts is catalyzed by the spliceosome, a
multicomponent complex that assembles on the newly synthesized pre-mRNA. Pre-mRNA …
multicomponent complex that assembles on the newly synthesized pre-mRNA. Pre-mRNA …
Structure of a transcribing RNA polymerase II–U1 snRNP complex
S Zhang, S Aibara, SM Vos, DE Agafonov, R Lührmann… - Science, 2021 - science.org
To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear
ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA) …
ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA) …
Molecular mechanisms of pre-mRNA splicing through structural biology of the spliceosome
Precursor messenger RNA (pre-mRNA) splicing is executed by the spliceosome. In the past
3 years, cryoelectron microscopy (cryo-EM) structures have been elucidated for a majority of …
3 years, cryoelectron microscopy (cryo-EM) structures have been elucidated for a majority of …
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
Most mammalian genes generate messenger RNAs with variable untranslated regions
(UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3′ UTR …
(UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3′ UTR …