Understanding the mechanisms of evolution requires information on the rate of appearance
of new mutations and their effects at the molecular and phenotypic levels. Although …

Synonymous codon changes, which do not alter protein sequence, were previously thought
to have no functional consequence. Although this concept has been overturned in recent …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Methods for detecting nucleotide substitution rates that are faster or slower than expected
under neutral drift are widely used to identify candidate functional elements in genomic …

Although mutation provides the fuel for phenotypic evolution, it also imposes a substantial
burden on fitness through the production of predominantly deleterious alleles, a matter of …

It has been known for many years that the mutation rate varies across the genome. However,
only with the advent of large genomic data sets is the full extent of this variation becoming …

The germline mutation rate is an important parameter that affects the amount of genetic
variation and the rate of evolution. However, neither the rate of germline mutations in …

With the advent of deep sequencing technologies and the ability to analyze whole genome
sequences and transcriptomes, there has been a growing interest in exploring putative …

Synonymous sites are generally assumed to be subject to weak selective constraint. For this
reason, they are often neglected as a possible source of important functional variation. We …

The evolution of sex is one of the most important and controversial problems in evolutionary
biology. Although sex is almost universal in higher animals and plants, its inherent costs …