Pervasive roles of microRNAs in cardiovascular biology
First recognized as regulators of development in worms and fruitflies, microRNAs are
emerging as pivotal modulators of mammalian cardiovascular development and disease …
emerging as pivotal modulators of mammalian cardiovascular development and disease …
Heparan sulfate biosynthesis: regulation and variability
Nearly all vertebrate cells have been shown to express heparan sulfate proteoglycans
(HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including …
(HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including …
miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells
MQ Hassan, Y Maeda, H Taipaleenmaki… - Journal of Biological …, 2012 - ASBMB
MicroRNAs (miRNAs) negatively and post-transcriptionally regulate expression of multiple
target genes to support anabolic pathways for bone formation. Here, we show that miR-218 …
target genes to support anabolic pathways for bone formation. Here, we show that miR-218 …
Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF
Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part
via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate …
via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate …
[HTML][HTML] The role of the Slit/Robo signaling pathway
The Slit family is a family of secreted proteins that play important roles in various physiologic
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …
Novel roles for Slits and netrins: axon guidance cues as anticancer targets?
Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …
for embryogenesis have been shown to regulate tumour development and progression by …
MicroRNA-218 Inhibits Glioma Invasion, Migration, Proliferation, and Cancer Stem-like Cell Self-Renewal by Targeting the Polycomb Group Gene Bmi1
Malignant gliomas are the most common central nervous system tumors and the molecular
mechanism driving their development and recurrence is still largely unknown, limiting the …
mechanism driving their development and recurrence is still largely unknown, limiting the …
Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization
Ocular neovascular diseases are a leading cause of blindness. Vascular endothelial growth
factor (VEGF) blockade improves vision, but not all individuals respond to anti-VEGF …
factor (VEGF) blockade improves vision, but not all individuals respond to anti-VEGF …
miRNAs as modulators of angiogenesis
S Landskroner-Eiger, I Moneke… - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
MicroRNAs are highly expressed in endothelial cells, and recent data suggest that they
regulate aspects of vascular development and angiogenesis. This study highlights the state …
regulate aspects of vascular development and angiogenesis. This study highlights the state …
MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein
The functional association between intronic miRNAs and their host genes is still largely
unknown. We found that three gene loci, which produced miR-26a and miR-26b, were …
unknown. We found that three gene loci, which produced miR-26a and miR-26b, were …