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Fox transcription factors: from development to disease
Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …
from yeast to humans. They regulate diverse biological processes both during development …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …
de-regulation of this timing promotes the formation of cancer and leads to defects during …
Building and regenerating the lung cell by cell
JA Whitsett, TV Kalin, Y Xu… - Physiological …, 2019 - journals.physiology.org
The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …
The emerging roles of forkhead box (Fox) proteins in cancer
SS Myatt, EWF Lam - Nature Reviews Cancer, 2007 - nature.com
Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional
regulators, which control a wide spectrum of biological processes. As a consequence, a loss …
regulators, which control a wide spectrum of biological processes. As a consequence, a loss …
Organogenesis and development of the liver
Embryonic development of the liver has been studied intensely, yielding insights that impact
diverse areas of developmental and cell biology. Understanding the fundamental …
diverse areas of developmental and cell biology. Understanding the fundamental …
FOXM1: From cancer initiation to progression and treatment
The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological
processes, including cell proliferation, cell cycle progression, cell differentiation, DNA …
processes, including cell proliferation, cell cycle progression, cell differentiation, DNA …
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase
The Forkhead box m1 (Foxm1) gene is critical for G1/S transition and essential for mitotic
progression. However, the transcriptional mechanisms downstream of FoxM1 that control …
progression. However, the transcriptional mechanisms downstream of FoxM1 that control …
FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression
G Hu, Z Yan, C Zhang, M Cheng, Y Yan… - Journal of Experimental …, 2019 - Springer
Abstract Background Forkhead box M1 (FOXM1) is a proliferation-associated transcription
factor of the forkhead box proteins superfamily, which includes four isoforms FOXM1a, b, c …
factor of the forkhead box proteins superfamily, which includes four isoforms FOXM1a, b, c …
FoxM1: at the crossroads of ageing and cancer
J Laoukili, M Stahl, RH Medema - … et Biophysica Acta (BBA)-Reviews on …, 2007 - Elsevier
Forkhead transcription factors are intimately involved in the regulation of organismal
development, cell differentiation and proliferation. Here we review the current knowledge of …
development, cell differentiation and proliferation. Here we review the current knowledge of …
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton
NS Hegde, DA Sanders, R Rodriguez… - Nature …, 2011 - nature.com
Transcription factors are proteins that bind specifically to defined DNA sequences to
promote gene expression. Targeting transcription factors with small molecules to modulate …
promote gene expression. Targeting transcription factors with small molecules to modulate …