Tics and functional tic-like movements: Can we tell them apart?

C Ganos, D Martino, AJ Espay, AE Lang, KP Bhatia… - Neurology, 2019 - AAN Enterprises
Within the broad spectrum of movement disorders, tics and functional tic-like movements
belong to a particular clinical category. Both types of movements are within the range of …

Dopaminergic disturbances in Tourette syndrome: an integrative account

TV Maia, VA Conceição - Biological psychiatry, 2018 - Elsevier
Tourette syndrome (TS) is thought to involve dopaminergic disturbances, but the nature of
those disturbances remains controversial. Existing hypotheses suggest that TS involves 1) …

Pallidal and thalamic neural oscillatory patterns in Tourette's syndrome

WJ Neumann, J Huebl, C Brücke, R Lofredi… - Annals of …, 2018 - Wiley Online Library
Objective Aberrant oscillatory activity has been hypothesized to play a role in the
pathophysiology of Tourette's syndrome (TS). Deep brain stimulation (DBS) has recently …

Monoacylglycerol lipase inhibition in Tourette syndrome: a 12‐week, randomized, controlled study

KR Müller‐Vahl, C Fremer, C Beals… - Movement …, 2021 - Wiley Online Library
Background Modulation of the endocannabinoid system via monoacylglycerol lipase
inhibition with Lu AG06466 (formerly known as ABX‐1431) has previously been shown to …

Merging the pathophysiology and pharmacotherapy of tics

F Augustine, HS Singer - Tremor and Other Hyperkinetic …, 2019 - pmc.ncbi.nlm.nih.gov
Background Anatomically, cortical-basal ganglia-thalamo-cortical (CBGTC) circuits have an
essential role in the expression of tics. At the biochemical level, the proper conveyance of …

Theory-based computational psychiatry

TV Maia, QJM Huys, MJ Frank - Biological …, 2017 - biologicalpsychiatryjournal.com
Cannot we be content with experiment alone? No, that is impossible; that would be a
complete misunderstanding of the true character of science.. Science is built up of facts, as a …

A Bayesian account of the sensory-motor interactions underlying symptoms of Tourette syndrome

CL Rae, HD Critchley, AK Seth - Frontiers in psychiatry, 2019 - frontiersin.org
Tourette syndrome is a hyperkinetic movement disorder. Characteristic features include tics,
recurrent movements that are experienced as compulsive and “unwilled”; uncomfortable …

Premonitory urges and tics in Tourette syndrome: computational mechanisms and neural correlates

VA Conceição, Â Dias, AC Farinha, TV Maia - Current opinion in …, 2017 - Elsevier
Highlights•The somatosensory cortices and the insula are implicated in premonitory
urges.•The insula may serve as a gateway between premonitory urges and …

Striatal dopaminergic alterations in Tourette's syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies

M Hienert, G Gryglewski, M Stamenkovic… - Translational …, 2018 - nature.com
Despite intense research, the underlying mechanisms and the etiology of Tourette's
syndrome (TS) remain unknown. Data from molecular imaging studies targeting the …

[HTML][HTML] General health and mortality in Tourette syndrome and chronic tic disorder: A mini-review

LF de la Cruz, D Mataix-Cols - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Current knowledge on the general somatic health and causes of death in Tourette syndrome
and chronic tic disorder is very limited. Here, we review the available literature on the topic …