Cellular mechanosignaling for sensing and transducing matrix rigidity
The mechanisms by which cells sense their mechanical environment and transduce the
signal through focal adhesions and signaling pathways to the nucleus is an area of key …
signal through focal adhesions and signaling pathways to the nucleus is an area of key …
Physiological and pathological roles of caveolins in the central nervous system
Caveolins are a family of transmembrane proteins located in caveolae, small lipid raft
invaginations of the plasma membrane. The roles of caveolin-enriched lipid rafts are …
invaginations of the plasma membrane. The roles of caveolin-enriched lipid rafts are …
A mechanosensitive caveolae–invadosome interplay drives matrix remodelling for cancer cell invasion
Invadosomes and caveolae are mechanosensitive structures that are implicated in
metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix …
metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix …
Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation
F Morales-Paytuví, A Fajardo, C Ruiz-Mirapeix… - Journal of Cell …, 2023 - rupress.org
Caveolin-1 (CAV1) and CAV3 are membrane-sculpting proteins driving the formation of the
plasma membrane (PM) caveolae. Within the PM mosaic environment, caveola assembly is …
plasma membrane (PM) caveolae. Within the PM mosaic environment, caveola assembly is …
Caveolae mechanotransduction at the interface between cytoskeleton and extracellular matrix
L Sotodosos-Alonso, M Pulgarín-Alfaro, MA Del Pozo - Cells, 2023 - mdpi.com
The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt
and respond to them. PM invaginations named caveolae, with a specific protein and lipid …
and respond to them. PM invaginations named caveolae, with a specific protein and lipid …
Mechanotransduction through membrane tension: It's all about propagation?
A Ghisleni, NC Gauthier - Current Opinion in Cell Biology, 2024 - Elsevier
Over the past 25 years, membrane tension has emerged as a primary mechanical factor
influencing cell behavior. Although supporting evidences are accumulating, the integration …
influencing cell behavior. Although supporting evidences are accumulating, the integration …
Caveolin-1 in endothelial cells: A potential therapeutic target for atherosclerosis
Y Shu, S ** - Heliyon, 2023 - cell.com
Atherosclerosis (AS) is a chronic vascular disease characterized by lipid accumulation and
the activation of the inflammatory response; it remains the leading nation-wide cause of …
the activation of the inflammatory response; it remains the leading nation-wide cause of …
Shape-dependent cellular uptake of iron oxide nanorods: mechanisms of endocytosis and implications on cell labeling and cellular delivery
The effects of nanoparticle morphology, especially size and shape, on their interactions with
cells are of great interest in understanding the fate of nanoparticles in biological systems …
cells are of great interest in understanding the fate of nanoparticles in biological systems …
The role of membrane lipids in the formation and function of caveolae
Caveolae are plasma membrane invaginations with a distinct lipid composition. Membrane
lipids cooperate with the structural components of caveolae to generate a metastable …
lipids cooperate with the structural components of caveolae to generate a metastable …
Single-Cell Mechanics: Structural Determinants and Functional Relevance
The mechanical phenotype of a cell determines its ability to deform under force and is
therefore relevant to cellular functions that require changes in cell shape, such as migration …
therefore relevant to cellular functions that require changes in cell shape, such as migration …