New twists in actin–microtubule interactions

ML Pimm, JL Henty-Ridilla - Molecular biology of the cell, 2021 - molbiolcell.org
Actin filaments and microtubules are cytoskeletal polymers that participate in many vital cell
functions including division, morphogenesis, phagocytosis, and motility. Despite the …

[HTML][HTML] Multiscale architecture: Mechanics of composite cytoskeletal networks

C Lorenz, S Köster - Biophysics Reviews, 2022 - pubs.aip.org
Different types of biological cells respond differently to mechanical stresses, and these
responses are mainly governed by the cytoskeleton. The main components of this …

Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics

G Lee, G Leech, MJ Rust, M Das, RJ McGorty… - Science …, 2021 - science.org
The cytoskeleton is a dynamic network of proteins, including actin, microtubules, and their
associated motor proteins, that enables essential cellular processes such as motility …

Optical-Tweezers-integrating-Differential-Dynamic-Microscopy maps the spatiotemporal propagation of nonlinear strains in polymer blends and composites

KR Peddireddy, R Clairmont, P Neill, R McGorty… - Nature …, 2022 - nature.com
How local stresses propagate through polymeric fluids, and, more generally, how
macromolecular dynamics give rise to viscoelasticity are open questions vital to wide …

Rabies virus exploits cytoskeleton network to cause early disease progression and cellular dysfunction

X Liu, Z Nawaz, C Guo, S Ali, MA Naeem… - Frontiers in Veterinary …, 2022 - frontiersin.org
Rabies virus (RABV) is a cunning neurotropic pathogen and causes top priority neglected
tropical diseases in the develo** world. The genome of RABV consists of nucleoprotein …

Active cytoskeletal composites display emergent tunable contractility and restructuring

G Lee, G Leech, P Lwin, J Michel, C Currie, MJ Rust… - Soft Matter, 2021 - pubs.rsc.org
The cytoskeleton is a model active matter system that controls processes as diverse as cell
motility and mechanosensing. While both active actomyosin dynamics and actin …

[HTML][HTML] DNA topology dictates emergent bulk elasticity and hindered macromolecular diffusion in DNA-dextran composites

P Khanal, KR Peddireddy, J Marfai, R McGorty… - Journal of …, 2022 - pubs.aip.org
Polymer architecture plays critical roles in both bulk rheological properties and microscale
macromolecular dynamics in entangled polymer solutions and composites. Ring polymers …

The host cytoskeleton functions as a pleiotropic scaffold: orchestrating regulation of the viral life cycle and mediating host antiviral innate immune responses

M Li, D Peng, H Cao, X Yang, S Li, HJ Qiu, LF Li - Viruses, 2023 - mdpi.com
Viruses are obligate intracellular parasites that critically depend on their hosts to initiate
infection, complete replication cycles, and generate new progeny virions. To achieve these …

Microtubules under mechanical pressure can breach dense actin networks

M Gélin, A Schaeffer, J Gaillard… - Journal of Cell …, 2023 - journals.biologists.com
The crosstalk between the actin network and microtubules is essential for cell polarity. It
orchestrates microtubule organization within the cell, driven by the asymmetry of actin …

DNA conformation dictates strength and flocculation in DNA–microtubule composites

KR Peddireddy, D Michieletto, G Aguirre… - ACS macro …, 2021 - ACS Publications
Polymer topology has been shown to play a key role in tuning the dynamics of complex
fluids and gels. At the same time, polymer composites, ubiquitous in everyday life, have …