Signalling mechanisms and cellular functions of SUMO

ACO Vertegaal - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

SUMO-mediated regulation of nuclear functions and signaling processes

X Zhao - Molecular cell, 2018 - cell.com
Since the discovery of SUMO twenty years ago, SUMO conjugation has become a widely
recognized post-translational modification that targets a myriad of proteins in many …

SUMOylation-mediated regulation of cell cycle progression and cancer

K Eifler, ACO Vertegaal - Trends in biochemical sciences, 2015 - cell.com
Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during
cell cycle progression. Many important cell cycle regulators, including many oncogenes and …

Pervasive protein thermal stability variation during the cell cycle

I Becher, A Andrés-Pons, N Romanov, F Stein… - Cell, 2018 - cell.com
Quantitative mass spectrometry has established proteome-wide regulation of protein
abundance and post-translational modifications in various biological processes. Here, we …

Sumo and the cellular stress response

JM Enserink - Cell division, 2015 - Springer
The ubiquitin family member Sumo has important functions in many cellular processes
including DNA repair, transcription and cell division. Numerous studies have shown that …

SUMO-mediated regulation of DNA damage repair and responses

P Sarangi, X Zhao - Trends in biochemical sciences, 2015 - cell.com
Sumoylation has important roles during DNA damage repair and responses. Recent broad-
scope and substrate-based studies have shed light on the regulation and significance of …

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

R Sonneville, SP Moreno, A Knebel, C Johnson… - Nature cell …, 2017 - nature.com
Replisome disassembly is the final step of DNA replication in eukaryotes, involving the
ubiquitylation and CDC48-dependent dissolution of the CMG helicase (CDC45–MCM …

A SUMO-dependent protein network regulates chromosome congression during oocyte meiosis

F Pelisch, T Tammsalu, B Wang, EG Jaffray, A Gartner… - Molecular cell, 2017 - cell.com
During Caenorhabditis elegans oocyte meiosis, a multi-protein ring complex (RC) localized
between homologous chromosomes, promotes chromosome congression through the action …

The role of SUMOylation during development

A Talamillo, O Barroso-Gomila… - Biochemical Society …, 2020 - portlandpress.com
During the development of multicellular organisms, transcriptional regulation plays an
important role in the control of cell growth, differentiation and morphogenesis. SUMOylation …

Global analysis of sumoylation function reveals novel insights into development and appressorium‐mediated infection of the rice blast fungus

C Liu, Z Li, J **ng, J Yang, Z Wang, H Zhang… - New …, 2018 - Wiley Online Library
Protein post‐translational modifications play critical roles in cellular processes, development
and stress response. The small ubiquitin‐like modifier (SUMO) to proteins is one of the …