ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to
anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 …

Chemotherapy and molecularly targeted approaches represent two very different modes of
cancer treatment and each is associated with unique benefits and limitations. Both types of …

Gene expression analysis may help the management of cancer patients, allowing the
selection of subjects responding to treatment. The aim of this study was the characterization …

The prescribed dose of anticancer agents is most commonly calculated using body surface
area as the only independent variable, and it has been shown that this approach still results …

Abstract BACKGROUND AND AIMS: The standard palliative chemotherapy for pancreatic
ductal adenocarcinoma (PDAC) is gemcitabine-based chemotherapy; however, PDAC still …

Inherent and acquired drug resistance is a cause of chemotherapy failure, and
pharmacogenomic studies have begun to define gene variations responsible for varied drug …

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the
catabolism of 5-fluorouracil (5FU) and a DPD deficiency is increasingly being recognized as …

The same doses of medication cause considerable heterogeneity in efficacy and toxicity
across human populations. Genetic factors are thought to represent important determinants …

Primary lung cancer is very heterogeneous in its clinical presentation, histopathology, and
treatment response; and like other diseases, the prognosis consists of two essential facets …

Successful treatment of cancer requires a clear understanding of drug‐resistance
mechanism. Cancer patient are often treated with standard protocols without considering …