[HTML][HTML] Health effects associated with humidifier disinfectant use: a systematic review for exploration

JH Song, J Ahn, MY Park, J Park… - Journal of Korean …, 2022 - synapse.koreamed.org
Background It has been 10 years since the outbreak of lung disease caused by humidifier
disinfectants in Korea, but the health effects have not yet been summarized. Therefore, this …

The past, present and future of humidifier disinfectant-associated interstitial lung diseases in children

E Lee, SY Lee, SJ Hong - Clinical and Experimental Pediatrics, 2019 - pmc.ncbi.nlm.nih.gov
Exposure to environmental factors can cause interstitial lung diseases (ILDs); however, such
types of ILDs are rare. From 2007 to 2011, an ILD epidemic occurred in South Korea owing …

Polyhexamethylene guanidine aerosol causes irreversible changes in blood proteins that associated with the severity of lung injury

HS Ahn, SY Lee, MJ Kang, SB Hong, JW Song… - Journal of Hazardous …, 2024 - Elsevier
Polyhexamethylene guanidine (PHMG) is a positively charged polymer used as a
disinfectant that kills microbes but can cause pulmonary fibrosis if inhaled. After the long …

Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat …

D Kim, Y Shin, EH Kim, Y Lee, S Kim, HS Kim, HC Kim… - Toxicology letters, 2022 - Elsevier
Abstract The mixture of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT,
chloromethylisothiazolinone) and 2-methyl-4-isothiazolin-3-one (MIT, methylisothiazolinone) …

3D Printed SERS-Active Thin-Film Substrates Used to Quantify Levels of the Genotoxic Isothiazolinone

S Jaitpal, SR Chavva, S Mabbott - ACS omega, 2022 - ACS Publications
Several reports present methods to fabricate thin-film substrates capable of surface-
enhanced Raman scattering (SERS). Substrates synthesized by displacing silver onto …

Different characteristics of childhood asthma related to polyhexamethylene guanidine exposure

SY Lee, HS Ahn, EM Kim, KK Kim, MJ Kang… - Annals of the …, 2021 - atsjournals.org
Rationale: Exposure to humidifier disinfectants (HDs) can increase the risk of asthma, but
the characteristics of HD-related asthma are currently unclear. Polyhexamethylene …

Prenatal exposure to heavy metals affects gestational age by altering DNA methylation patterns

EJ Koh, SY Yu, SH Kim, JS Lee, SY Hwang - Nanomaterials, 2021 - mdpi.com
Environmental exposure is known to have toxic effects. Maternal environmental exposure
not only affects mothers but also their fetuses in utero, which may interrupt their early …

[HTML][HTML] Polyhexamethylene Guanidine Phosphate Induces Restrictive Ventilation Defect and Alters Lung Resistance and Compliance in Mice

YH Park, SH Jeong, H Lee, YJ Nam, H Lee, YS Lee… - Toxics, 2024 - mdpi.com
Polyhexamethylene guanidine phosphate (PHMG-p), a major ingredient of humidifier
disinfectants, is known to induce inflammation, interstitial pneumonitis, and fibrosis in the …

[HTML][HTML] Fibrosis as a result of polyhexamethylene guanide exposure in cultured Statens Seruminstitut Rabbit Cornea (SIRC) cells

H Lee, J Park, K Park - Environmental Analysis, Health and …, 2021 - ncbi.nlm.nih.gov
Previous research studies on the toxicity of polyhexamethylene guanidine (PHMG) as a
humidifier disinfectant majorly focused on lung fibrosis. Considering that disinfectants in …

Assessment of agonistic and antagonistic properties of humidifier disinfectants to the estrogenic and androgenic receptors by transactivation assay

H Lee, J Park, K Park - Toxicological Research, 2022 - Springer
Before being recalled and banned from the Korean market, humidifier disinfectants (HDs)
were added to the humidifier water tank to prevent microbial growth. The known HDs active …