For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Innate and adaptive immunity represent a harmonic counterbalanced system involved in the
induction, progression, and possibly resolution of the inflammatory reaction that characterize …

Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Tissue-resident macrophages play important roles in tissue homeostasis and repair.
However, how macrophages monitor and maintain tissue integrity is not well understood …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Significance: The aberrant inflammation during wound healing results in pathological
scarring, such as hypertrophic scars and keloids. This adversely affects the quality of life of …

Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic
wounds, and macrophage malfunction is considered as a major contributor thereof. In this …