Polycystic ovary syndrome: etiology, current management, and future therapeutics
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically
characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries …
characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries …
The impact of the gut microbiota on the reproductive and metabolic endocrine system
X Qi, C Yun, Y Pang, J Qiao - Gut microbes, 2021 - Taylor & Francis
As the gut microbiota exerts various effects on the intestinal milieu which influences distant
organs and pathways, it is considered to be a full-fledged endocrine organ. The microbiota …
organs and pathways, it is considered to be a full-fledged endocrine organ. The microbiota …
A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea
The gut microbiota represents a large community of microorganisms that play an important
role in immune regulation and maintenance of homeostasis. Living bacteria receive …
role in immune regulation and maintenance of homeostasis. Living bacteria receive …
Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate
R Wang, X Yang, J Liu, F Zhong, C Zhang… - Nature …, 2022 - nature.com
The gut microbiota has been linked to many cancers, yet its role in acute myeloid leukaemia
(AML) progression remains unclear. Here, we show decreased diversity in the gut …
(AML) progression remains unclear. Here, we show decreased diversity in the gut …
Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption
X Li, J Yang, X Zhou, C Dai, M Kong, L **e, C Liu… - Nature …, 2024 - nature.com
The low-carbohydrate ketogenic diet (KD) has long been practiced for weight loss, but the
underlying mechanisms remain elusive. Gut microbiota and metabolites have been …
underlying mechanisms remain elusive. Gut microbiota and metabolites have been …
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target
K Wang, Z Zhang, J Hang, J Liu, F Guo, Y Ding, M Li… - Science, 2023 - science.org
A mechanistic understanding of how microbial proteins affect the host could yield deeper
insights into gut microbiota–host cross-talk. We developed an enzyme activity–screening …
insights into gut microbiota–host cross-talk. We developed an enzyme activity–screening …
How bile acids and the microbiota interact to shape host immunity
Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various
host processes. Similarly, there is growing attention on members of the microbiota that are …
host processes. Similarly, there is growing attention on members of the microbiota that are …
Understanding the genetics of human infertility
Q Sang, PF Ray, L Wang - Science, 2023 - science.org
Reproduction involves a wide range of biological processes, including organ formation and
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …
Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …
Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer
H Teng, Y Wang, X Sui, J Fan, S Li, X Lei, C Shi, W Sun… - Cancer Cell, 2023 - cell.com
Preoperative neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally
advanced rectal cancer (LARC) patients, yet little is known about the mediators underlying …
advanced rectal cancer (LARC) patients, yet little is known about the mediators underlying …