Polycystic ovary syndrome: etiology, current management, and future therapeutics

S Singh, N Pal, S Shubham, DK Sarma… - Journal of Clinical …, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically
characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries …

The impact of the gut microbiota on the reproductive and metabolic endocrine system

X Qi, C Yun, Y Pang, J Qiao - Gut microbes, 2021 - Taylor & Francis
As the gut microbiota exerts various effects on the intestinal milieu which influences distant
organs and pathways, it is considered to be a full-fledged endocrine organ. The microbiota …

A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea

J Pan, G Gong, Q Wang, J Shang, Y He… - Nature …, 2022 - nature.com
The gut microbiota represents a large community of microorganisms that play an important
role in immune regulation and maintenance of homeostasis. Living bacteria receive …

Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

R Wang, X Yang, J Liu, F Zhong, C Zhang… - Nature …, 2022 - nature.com
The gut microbiota has been linked to many cancers, yet its role in acute myeloid leukaemia
(AML) progression remains unclear. Here, we show decreased diversity in the gut …

Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption

X Li, J Yang, X Zhou, C Dai, M Kong, L **e, C Liu… - Nature …, 2024 - nature.com
The low-carbohydrate ketogenic diet (KD) has long been practiced for weight loss, but the
underlying mechanisms remain elusive. Gut microbiota and metabolites have been …

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target

K Wang, Z Zhang, J Hang, J Liu, F Guo, Y Ding, M Li… - Science, 2023 - science.org
A mechanistic understanding of how microbial proteins affect the host could yield deeper
insights into gut microbiota–host cross-talk. We developed an enzyme activity–screening …

How bile acids and the microbiota interact to shape host immunity

MH Lee, SP Nuccio, I Mohanty, LR Hagey… - Nature Reviews …, 2024 - nature.com
Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various
host processes. Similarly, there is growing attention on members of the microbiota that are …

Understanding the genetics of human infertility

Q Sang, PF Ray, L Wang - Science, 2023 - science.org
Reproduction involves a wide range of biological processes, including organ formation and
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …

Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer

H Teng, Y Wang, X Sui, J Fan, S Li, X Lei, C Shi, W Sun… - Cancer Cell, 2023 - cell.com
Preoperative neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally
advanced rectal cancer (LARC) patients, yet little is known about the mediators underlying …