Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …

Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and
have a key role in the epigenetic regulation of gene expression. In addition, the activity of …

This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …

The role of histone deacetylases (HDAC) and the potential of these enzymes as therapeutic
targets for cancer, neurodegenerative diseases and a number of other disorders is an area …

Polycomb-repressive complex 2 (PRC2)-mediated histone methylation plays an important
role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we …

Initially regarded as “epigenetic modifiers” acting predominantly through chromatin
remodeling via histone acetylation, HDACIs, alternatively referred to as lysine deacetylase …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

Importance of the field: Histone deacetylase (HDAC) inhibitors are being developed as a
new, targeted class of anticancer drugs. Area covered in this review: This review focuses on …

Abstract Thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH are key members of
the Trx system that is involved in redox regulation and antioxidant defense. In recent years …

The identification of recurrent somatic mutations in genes encoding epigenetic enzymes has
provided a strong rationale for the development of compounds that target the epigenome for …