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Therapeutically exploiting STAT3 activity in cancer—using tissue repair as a road map
The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …
Mechanisms and consequences of Jak–STAT signaling in the immune system
Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …
('signal transducer and activator of transcription') family constitute a rapid membrane-to …
Genomic profiling for clinical decision making in lymphoid neoplasms
With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
A phase 2 biomarker-driven study of ruxolitinib demonstrates effectiveness of JAK/STAT targeting in T-cell lymphomas
AJ Moskowitz, P Ghione, E Jacobsen… - Blood, The Journal …, 2021 - ashpublications.org
Signaling through JAK1 and/or JAK2 is common among tumor and nontumor cells within
peripheral T-cell lymphoma (PTCL). No oral therapies are approved for PTCL, and better …
peripheral T-cell lymphoma (PTCL). No oral therapies are approved for PTCL, and better …
The 2016 revision of the World Health Organization classification of lymphoid neoplasms
SH Swerdlow, E Campo, SA Pileri… - Blood, The Journal …, 2016 - ashpublications.org
A revision of the nearly 8-year-old World Health Organization classification of the lymphoid
neoplasms and the accompanying monograph is being published. It reflects a consensus …
neoplasms and the accompanying monograph is being published. It reflects a consensus …
The JAK-STAT pathway: impact on human disease and therapeutic intervention
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
C Xue, Q Yao, X Gu, Q Shi, X Yuan, Q Chu… - Signal transduction and …, 2023 - nature.com
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
LGL leukemia: from pathogenesis to treatment
T Lamy, A Moignet… - Blood, The Journal of the …, 2017 - ashpublications.org
Large granular lymphocyte (LGL) leukemia has been recognized by the World Health
Organization classifications amongst mature T-cell and natural killer (NK) cell neoplasms …
Organization classifications amongst mature T-cell and natural killer (NK) cell neoplasms …
JAKs and STATs from a clinical perspective: loss-of-function mutations, gain-of-function mutations, and their multidimensional consequences
N Ott, L Faletti, M Heeg, V Andreani… - Journal of clinical …, 2023 - Springer
The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
Diagnosis and classification of hematologic malignancies on the basis of genetics
Genomic analysis has greatly influenced the diagnosis and clinical management of patients
affected by diverse forms of hematologic malignancies. Here, we review how genetic …
affected by diverse forms of hematologic malignancies. Here, we review how genetic …