Defining necrotizing enterocolitis: current difficulties and future opportunities

RM Patel, J Ferguson, SJ McElroy, M Khashu… - Pediatric …, 2020 - nature.com
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in hospitalized
infants. First classified through Bell staging in 1978, a number of additional definitions of …

Necrotizing enterocolitis

J Duchon, ME Barbian… - Clinics in …, 2021 - perinatology.theclinics.com
Necrotizing enterocolitis (NEC) is a devastating intestinal disorder characterized by
intestinal inflammation and necrosis. 1 This disease is one of the most common …

Necrotizing enterocolitis: long term complications

C Bazacliu, J Neu - Current pediatric reviews, 2019 - ingentaconnect.com
Necrotizing enterocolitis (NEC) remains the most threatening gastrointestinal complication of
prematurity leading to high mortality, morbidity and cost. Common complications of NEC …

Oxidative stress in preterm newborns

C Lembo, G Buonocore, S Perrone - Antioxidants, 2021 - mdpi.com
Preterm babies are highly susceptible to oxidative stress (OS) due to an imbalance between
the oxidant and antioxidant systems. The generation of free radicals (FR) induces oxidative …

Necrotizing enterocolitis

J Bellodas Sanchez, M Kadrofske - Neurogastroenterology & …, 2019 - Wiley Online Library
Necrotizing enterocolitis (NEC) is an acute inflammatory disease of the intestine which
primarily affects preterm infants and is a leading cause of morbidity and mortality in the …

Reassessing acquired neonatal intestinal diseases using unsupervised machine learning

DR Gipson, AL Chang, AC Lure, SA Mehta… - Pediatric …, 2024 - nature.com
Background Acquired neonatal intestinal diseases have an array of overlap**
presentations and are often labeled under the dichotomous classification of necrotizing …

Challenges in diagnosing necrotizing enterocolitis

JH Kim, V Sampath, J Canvasser - Pediatric research, 2020 - nature.com
One of the many challenges with necrotizing enterocolitis (NEC) remains our inability to
make an accurate diagnosis of NEC. The lack of a unifying cause and multiple variations in …

Emerging biomarkers for prediction and early diagnosis of necrotizing enterocolitis in the era of metabolomics and proteomics

E Agakidou, C Agakidis, H Gika, K Sarafidis - Frontiers in Pediatrics, 2020 - frontiersin.org
Necrotizing Enterocolitis (NEC) is a catastrophic disease affecting predominantly premature
infants and is characterized by high mortality and serious long-term consequences …

New insights into necrotizing enterocolitis: from laboratory observation to personalized prevention and treatment

DJ Hackam, CP Sodhi, M Good - Journal of pediatric surgery, 2019 - Elsevier
Background/purpose Necrotizing enterocolitis (NEC) is a devastating disease of prematurity
that develops after feeding, often without warning, and results in diffuse intestinal necrosis …

Spontaneous intestinal perforation (SIP) will soon become the most common form of surgical bowel disease in the extremely low birth weight (ELBW) infant

JR Swanson, A Hair, RH Clark, PV Gordon - Journal of Perinatology, 2022 - nature.com
Recent data have revealed declines in the prevalence rates of NEC over the last decade in
premature infants. In contrast, SIP has either remained steady or risen during the same …