Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction

M Galli, G Niccoli, G De Maria, S Brugaletta… - Nature Reviews …, 2024 - nature.com
Despite prompt epicardial recanalization in patients presenting with ST-segment elevation
myocardial infarction (STEMI), coronary microvascular obstruction and dysfunction (CMVO) …

Coronary angiography after cardiac arrest without ST-segment elevation

JS Lemkes, GN Janssens… - … England Journal of …, 2019 - Mass Medical Soc
Background Ischemic heart disease is a major cause of out-of-hospital cardiac arrest. The
role of immediate coronary angiography and percutaneous coronary intervention (PCI) in …

The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge

G Heusch, BJ Gersh - European heart journal, 2017 - academic.oup.com
The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

Evolving therapies for myocardial ischemia/reperfusion injury

B Ibáñez, G Heusch, M Ovize, F Van de Werf - Journal of the American …, 2015 - jacc.org
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …

Coronary microvascular obstruction: the new frontier in cardioprotection

G Heusch - Basic Research in Cardiology, 2019 - Springer
Cardioprotection aims at infarct size reduction and improvement of clinical outcome from
myocardial infarction. The translation of cardioprotection from preclinical and promising …

Remote ischemic conditioning

G Heusch, HE Bøtker, K Przyklenk, A Redington… - Journal of the American …, 2015 - jacc.org
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with
reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and …

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

DJ Hausenloy, D Garcia-Dorado… - Cardiovascular …, 2017 - academic.oup.com
Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Coronary microvascular obstruction in acute myocardial infarction

G Niccoli, G Scalone, A Lerman… - European heart …, 2016 - academic.oup.com
The success of a primary percutaneous intervention (PCI) in the setting of ST elevation
myocardial infarction depends on the functional and structural integrity of coronary …

Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations

DJ Hausenloy, HE Botker, T Engstrom… - European heart …, 2017 - academic.oup.com
Ischaemic heart disease (IHD) remains the leading cause of death and disability in Europe
and worldwide. A major cause of morbidity and mortality in IHD patients is an acute ST …