[HTML][HTML] Transmembrane β-barrels: Evolution, folding and energetics
The biogenesis of transmembrane β-barrels (outer membrane proteins, or OMPs) is an
elaborate multistep orchestration of the nascent polypeptide with translocases, barrel …
elaborate multistep orchestration of the nascent polypeptide with translocases, barrel …
Cysteine oxidations in mitochondrial membrane proteins: the case of VDAC isoforms in mammals
S Reina, MGG Pittalà, F Guarino, A Messina… - Frontiers in cell and …, 2020 - frontiersin.org
Cysteine residues are reactive amino acids that can undergo several modifications driven by
redox reagents. Mitochondria are the source of an abundant production of radical species …
redox reagents. Mitochondria are the source of an abundant production of radical species …
[HTML][HTML] VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications
Abstract Voltage-Dependent Anion selective Channels (VDAC) are pore-forming
mitochondrial outer membrane proteins. In mammals VDAC3, the least characterized …
mitochondrial outer membrane proteins. In mammals VDAC3, the least characterized …
[HTML][HTML] Role of cysteines in mammalian VDAC isoforms' function
In this mini-review, we analyze the influence of cysteines in the structure and activity of
mitochondrial outer membrane mammalian VDAC isoforms. The three VDAC isoforms show …
mitochondrial outer membrane mammalian VDAC isoforms. The three VDAC isoforms show …
[HTML][HTML] VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore
M Okazaki, K Kurabayashi, M Asanuma, Y Saito… - … et Biophysica Acta (BBA …, 2015 - Elsevier
The voltage-dependent anion channels (VDACs), VDAC1, VDAC2, and VDAC3, are pore-
forming proteins that control metabolite flux between mitochondria and cytoplasm. VDAC1 …
forming proteins that control metabolite flux between mitochondria and cytoplasm. VDAC1 …
Succination is increased on select proteins in the brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) knockout mouse, a model of Leigh …
GG Piroli, AM Manuel, AC Clapper, MD Walla… - Molecular & Cellular …, 2016 - ASBMB
Elevated fumarate concentrations as a result of Krebs cycle inhibition lead to increases in
protein succination, an irreversible post-translational modification that occurs when fumarate …
protein succination, an irreversible post-translational modification that occurs when fumarate …
Cellular interactome of mitochondrial voltage-dependent anion channels: oligomerization and channel (mis) regulation
A Khan, G Kuriachan… - ACS Chemical …, 2021 - ACS Publications
Voltage-dependent anion channels (VDACs) of the outer mitochondrial membrane are
known conventionally as metabolite flux proteins. However, research findings in the past …
known conventionally as metabolite flux proteins. However, research findings in the past …
Folding and stability of integral membrane proteins in amphipols
JH Kleinschmidt, JL Popot - Archives of biochemistry and biophysics, 2014 - Elsevier
Amphipols (APols) are a family of amphipathic polymers designed to keep transmembrane
proteins (TMPs) soluble in aqueous solutions in the absence of detergent. APols have …
proteins (TMPs) soluble in aqueous solutions in the absence of detergent. APols have …
Voltage-dependent anion channels: the wizard of the mitochondrial outer membrane
Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer
mitochondrial membrane. Although they are essential in metabolite exchange, cell defense …
mitochondrial membrane. Although they are essential in metabolite exchange, cell defense …
Mitochondrial VDAC2 and cell homeostasis: highlighting hidden structural features and unique functionalities
Voltage‐dependent anion channels (VDACs) are the gateway to mitochondrial processes,
interlinking the cytosolic and mitochondrial compartments. The mitochondrion acts as a …
interlinking the cytosolic and mitochondrial compartments. The mitochondrion acts as a …