Many thousands of small molecule natural products with interesting biological activities are
polyketides (PK), nonribosomal peptides (NRP), or hybrids thereof (ie, PK-NRP hybrids) …

Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …

The rich diversity of secondary metabolites produced by soil bacteria has been appreciated
for over a century, and advances in chemical analysis and genome sequencing continue to …

Horizontal gene transfer is an important mechanism for the evolution of microbial genomes.
Pathogenicity islands—mobile genetic elements that contribute to rapid changes in …

Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of
Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of …

Covering: up to 2013 Although holo-acyl carrier protein synthase, AcpS, a
phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until …

Covering: up to 2012 With the recent structural characterization of each of the component
enzymes of type I polyketide synthases, scientists are coming tantalizingly close to …

The bacterial multienzyme polyketide synthases (PKSs) produce a diverse array of products
that have been developed into medicines, including antibiotics and anticancer agents. The …

Covering: up to the end of 2006 This review chronicles the synergistic growth of the fields of
fatty acid and polyketide synthesis over the last century. In both animal fatty acid synthases …