Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Epigenetic mechanisms, primarily mediated through histone and DNA modifications, play a
pivotal role in orchestrating the functional identity of a cell and its response to environmental …

Epigenetic alterations are a fundamental pathological hallmark of Alzheimer's disease (AD).
Herein, we show the upregulation of G9a and H3K9me2 in the brains of AD patients …

Long interspersed nuclear elements (LINEs) play essential roles in sha** chromatin
states, while the factors that cooperate with LINEs and their roles in higher‐order chromatin …

Introduction: The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known
as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the …

Gene expression is regulated by chromatin architecture and epigenetic remodeling in cell
homeostasis and pathologies. Histone modifications act as the key factors to modulate the …

Epigenetic dysregulation is a hallmark of Acute Myeloid Leukemia (AML), with mutations in
DNA Methyltransferases (eg, DNMT3A) being frequent and promising therapeutic targets …

Dysregulation of the tumor‐intrinsic epigenetic circuit is a key driver event for the
development of cancer. Accumulating evidence suggests that epigenetic and/or genetic …

Epigenetic alterations are a fundamental pathological hallmark of Alzheimer's disease (AD).
Herein, we show the upregulation of G9a and H3K9me2 in the brains of AD patients …

Histone H3 lysine 9 dimethylation (H3K9me2) is a repressive histone modification
associated with the formation of large, cell type-specific, facultative heterochromatin …