Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …

Gene regulation is a complex and tightly controlled process that defines cell identity, health
and disease, and response to pharmacologic and environmental signals. Recently …

DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …

The risk for major depression is both genetically and environmentally determined. It has
been proposed that epigenetic mechanisms could mediate the lasting increases in …

For a long time, scientists have tried to describe disorders just by genetic or environmental
factors. However, the role of epigenetics in human diseases has been considered from a …

Epigenetic mechanisms—including DNA methylation, histone post-translational
modifications and changes in nucleosome positioning—regulate gene expression, cellular …

A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …

Recent genome-sequencing studies in human neurodevelopmental and psychiatric
disorders have uncovered mutations in many chromatin regulators. These human genetic …

L1 retrotransposons are an abundant class of transposable elements that pose a threat to
genome stability and may have a role in age-related pathologies such as cancer. Recent …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …