The translation of cell-based therapies: clinical landscape and manufacturing challenges
Cell-based therapies have the potential to make a large contribution toward currently unmet
patient need and thus effective manufacture of these products is essential. Many challenges …
patient need and thus effective manufacture of these products is essential. Many challenges …
Induced pluripotent stem cells for cardiovascular disease modeling and precision medicine: a scientific statement from the American Heart Association
K Musunuru, F Sheikh, RM Gupta… - Circulation: Genomic …, 2018 - Am Heart Assoc
Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …
physiology and disease at the cellular level. They also have the potential to be leveraged in …
[HTML][HTML] Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform
C Denning, V Borgdorff, J Crutchley, KSA Firth… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …
Cryopreservation of human stem cells for clinical application: a review
CJ Hunt - Transfusion Medicine and Hemotherapy, 2011 - karger.com
Stem cells have been used in a clinical setting for many years. Haematopoietic stem cells
have been used for the treatment of both haematological and non-haematological disease; …
have been used for the treatment of both haematological and non-haematological disease; …
[HTML][HTML] Progress and challenges in large-scale expansion of human pluripotent stem cells
The constant supply of high cell numbers generated by defined, robust, and economically
viable culture processes is indispensable for the envisioned application of human …
viable culture processes is indispensable for the envisioned application of human …
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs) are an essential tool for modeling how causal genetic
variants impact cellular function in disease, as well as an emerging source of tissue for …
variants impact cellular function in disease, as well as an emerging source of tissue for …
Scalable expansion of human pluripotent stem cells in suspension culture
Routine commercial and clinical applications of human pluripotent stem cells (hPSCs) and
their progenies will require increasing cell quantities that cannot be provided by …
their progenies will require increasing cell quantities that cannot be provided by …
Human pluripotent stem cell culture: current status, challenges, and advancement
S Dakhore, B Nayer, K Hasegawa - Stem cells international, 2018 - Wiley Online Library
Over the past two decades, human embryonic stem cells (hESCs) have gained attention due
to their pluripotent and proliferative ability which enables production of almost all cell types …
to their pluripotent and proliferative ability which enables production of almost all cell types …
Stem cell cultivation in bioreactors
Cell-based therapies have generated great interest in the scientific and medical
communities, and stem cells in particular are very appealing for regenerative medicine, drug …
communities, and stem cells in particular are very appealing for regenerative medicine, drug …
Cell sheet engineering for regenerative medicine: current challenges and strategies
Substantial progress made in the areas of stem cell research and regenerative medicine has
provided a number of innovative methods to repair or regenerate defective tissues and …
provided a number of innovative methods to repair or regenerate defective tissues and …