Over the last decade, accumulating evidence has suggested a causative link between
mitochondrial dysfunction and major phenotypes associated with aging. Somatic …

Oxidative stress is now recognized as accountable for redox regulation involving reactive
oxygen species (ROS) and reactive nitrogen species (RNS). Its role is pivotal for the …

Glutathione (GSH) significantly declines in the aging rat liver. Because GSH levels are partly
a reflection of its synthetic capacity, we measured the levels and activity of γ …

Since the first mitochondrial dysfunction was described in the 1960s, the medicine has
advanced in its understanding the role mitochondria play in health, disease, and aging. A …

Aged mammalian tissues show a decreased capacity to produce ATP by oxidative
phosphorylation due to dysfunctional mitochondria. The mitochondrial content of rat brain …

Oxidative stress is at the forefront of Alzheimer disease (AD) research. While its implications
in the characteristic neurodegeneration of AD are vast, the most important aspect is that it …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Sulfur is an essential element for the entire biological kingdom because of its incorporation
into amino acids, proteins and other biomolecules. Sulfur atoms are also important in the …

Accumulation of oxidative damage to mitochondria, protein, and nucleic acid in the brain
may lead to neuronal and cognitive dysfunction. The effects on cognitive function, brain …

Neurodegeneration is a broadly defined term that describes the loss of neuronal structure
and function, and produces disorders known as neurodegenerative diseases. A common …