Neurotrophins: roles in neuronal development and function
EJ Huang, LF Reichardt - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …
Trk receptors: roles in neuronal signal transduction
EJ Huang, LF Reichardt - Annual review of biochemistry, 2003 - annualreviews.org
▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …
Classical electrostatics in biology and chemistry
A major revival in the use of classical electrostatics as an approach to the study of charged
and polar molecules in aqueous solution has been made possible through the development …
and polar molecules in aqueous solution has been made possible through the development …
Neurotrophin-regulated signalling pathways
LF Reichardt - … Transactions of the Royal Society B …, 2006 - royalsocietypublishing.org
Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …
factors for sensory and sympathetic neurons, and have since been shown to control many …
Nerve growth factor signaling, neuroprotection, and neural repair
▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …
Pfam: a comprehensive database of protein domain families based on seed alignments
Databases of multiple sequence alignments are a valuable aid to protein sequence
classification and analysis. One of the main challenges when constructing such a database …
classification and analysis. One of the main challenges when constructing such a database …
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system
M Bibel, YA Barde - Genes & development, 2000 - genesdev.cshlp.org
Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …
of the nervous system. They are generated in remarkable numbers, particularly in higher …
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …
Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
KR Jones, I Fariñas, C Backus, LF Reichardt - Cell, 1994 - cell.com
Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and
differentiation of several classes of neurons in vitro. To determine fts esaential functions, we …
differentiation of several classes of neurons in vitro. To determine fts esaential functions, we …
Crystal structure of human chorionic gonadotropin
The three-dimensional structure of human chorionic gonadotropin shows that each of its two
different subunits has a similar topology, with three disulphide bonds forming a cystine knot …
different subunits has a similar topology, with three disulphide bonds forming a cystine knot …