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The dual nature of type I and type II interferons
Type I and type II interferons (IFN) are central to both combating virus infection and
modulating the antiviral immune response. Indeed, an absence of either the receptor for type …
modulating the antiviral immune response. Indeed, an absence of either the receptor for type …
CD8+ T cell exhaustion and cancer immunotherapy
Q Wang, Y Qin, B Li - Cancer letters, 2023 - Elsevier
Immunotherapy plays an increasingly important role in the treatment of most malignant
tumors, and CD8+ T cells are the most important antitumor effector cells in the process of …
tumors, and CD8+ T cells are the most important antitumor effector cells in the process of …
Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …
Combination cancer therapy with immune checkpoint blockade: mechanisms and strategies
The success of immune checkpoint blockade in patients with a wide variety of malignancies
has changed the treatment paradigm in oncology. However, combination therapies with …
has changed the treatment paradigm in oncology. However, combination therapies with …
Host-directed therapies for bacterial and viral infections
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …
Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
Therapeutic blocking of the PD1 pathway results in significant tumor responses, but
resistance is common. We demonstrate that prolonged interferon signaling orchestrates …
resistance is common. We demonstrate that prolonged interferon signaling orchestrates …
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
Astrocytes have important roles in the central nervous system (CNS) during health and
disease. Through genome-wide analyses we detected a transcriptional response to type I …
disease. Through genome-wide analyses we detected a transcriptional response to type I …
Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice
Highly pathogenic human respiratory coronaviruses cause acute lethal disease
characterized by exuberant inflammatory responses and lung damage. However, the factors …
characterized by exuberant inflammatory responses and lung damage. However, the factors …
Molecular and cellular insights into T cell exhaustion
In chronic infections and cancer, T cells are exposed to persistent antigen and/or
inflammatory signals. This scenario is often associated with the deterioration of T cell …
inflammatory signals. This scenario is often associated with the deterioration of T cell …
CD8 T cell exhaustion during chronic viral infection and cancer
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
and cancers in animal models and humans. Tex cells are characterized by progressive loss …