Periodontitis is a complex disease:(a) various causative factors play a role simultaneously
and interact with each other; and (b) the disease is episodic in nature, and bursts of disease …

Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the
intestinal mucosa and unknown etiology. In this review, we identified three main eras in the …

AI is remarkably successful and outperforms human experts in certain tasks, even in
complex domains such as medicine. Humans on the other hand are experts at multi-modal …

There is a need for new therapeutic targets with which to prevent Alzheimer's disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …

ABSTRACT A capability for analyzing complex cellular communication among tissues is
important in drug discovery and development, and in vitro technologies for doing so are …

Traumatic brain injury (TBI) has been called “the most complicated disease of the most
complex organ of the body” and is an increasingly high-profile public health issue. Many …

Galvanized with the availability of sophisticated statistical techniques and large datasets,
network medicine has emerged as an active area of investigation. Following this trend …

Protein-protein interaction (PPI) networks are viable tools to understand cell functions,
disease machinery, and drug design/repositioning. Interpreting a PPI, however, it is a …

Discovering disease pathways, which can be defined as sets of proteins associated with a
given disease, is an important problem that has the potential to provide clinically actionable …

The 'precision medicine (systems medicine)'concept promises to achieve a shift to future
healthcare systems with a more proactive and predictive approach to medicine, where the …