Drug delivery to solid tumour involves multiple physiological, biochemical and biophysical
processes taking place across a wide range of length and time scales. The therapeutic …

Microneedle-mediated transdermal delivery using nanocarriers can successfully overcome
the barrier of the stratum corneum and protect drugs from elimination in skin tissues …

Personalised drug delivery enables a tailored treatment plan for each patient compared to
conventional drug delivery, where a generic strategy is commonly employed. It can not only …

The solute transport distribution in a tumor is an important criterion in the evaluation of the
cancer treatment efficacy. The fraction of killed cells after each treatment can quantify the …

Convection enhanced delivery (CED) of chemotherapeutic drugs can successfully bypass
the blood-brain barrier (BBB). However, the treatment efficacy is significantly variable in …

The present study examines chemotherapy by incorporating multi-scale mathematical
modeling to predict drug delivery and its effects. This approach leads to a more-realistic …

Vascular normalization (VN) by anti-angiogenic factors may be efficacious for improving
drug delivery in solid tumors. In the present study, a 3D computational model is employed to …

Although intraperitoneal chemotherapy (IPC) has been suggested as a promising method
for the management of peritoneal dissemination (PD) of ovarian or colorectal cancers, the …

Although intraperitoneal chemotherapy (IPC) has evolved into an established treatment
modality for patients with peritoneal metastasis (PM), drug penetration into tumor nodules …

Systemic toxicity and insufficient drug accumulation at the tumour site are main barriers in
chemotherapy. Thermosensitive liposomes (TSL) combined with high intensity focused …