Non-invasive transcranial ultrasound stimulation for neuromodulation
Transcranial ultrasound stimulation (TUS) holds great potential as a tool to alter neural
circuits non-invasively in both animals and humans. In contrast to established non-invasive …
circuits non-invasively in both animals and humans. In contrast to established non-invasive …
Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …
A pilot study of focused ultrasound thalamotomy for essential tremor
Background Recent advances have enabled delivery of high-intensity focused ultrasound
through the intact human cranium with magnetic resonance imaging (MRI) guidance. This …
through the intact human cranium with magnetic resonance imaging (MRI) guidance. This …
Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation
Transcranial focused ultrasound (tFUS) is a promising neuromodulation technique, but its
mechanisms remain unclear. We hypothesize that if tFUS parameters exhibit distinct …
mechanisms remain unclear. We hypothesize that if tFUS parameters exhibit distinct …
High intensity focused ultrasound: physical principles and devices
High intensity focused ultrasound (HIFU) is gaining rapid clinical acceptance as a treatment
modality enabling non-invasive tissue heating and ablation for numerous applications. HIFU …
modality enabling non-invasive tissue heating and ablation for numerous applications. HIFU …
Neuromodulation with single‐element transcranial focused ultrasound in human thalamus
Transcranial focused ultrasound (tFUS) has proven capable of stimulating cortical tissue in
humans. tFUS confers high spatial resolutions with deep focal lengths and as such, has the …
humans. tFUS confers high spatial resolutions with deep focal lengths and as such, has the …
Transcranial magnetic resonance imaging–guided focused ultrasound surgery of brain tumors: initial findings in 3 patients
OBJECTIVE This work evaluated the clinical feasibility of transcranial magnetic resonance
imaging–guided focused ultrasound surgery. METHODS Transcranial magnetic resonance …
imaging–guided focused ultrasound surgery. METHODS Transcranial magnetic resonance …
Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system
The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
Offline impact of transcranial focused ultrasound on cortical activation in primates
To understand brain circuits it is necessary both to record and manipulate their activity.
Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation …
Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation …
Current approaches to enhance CNS delivery of drugs across the brain barriers
CT Lu, YZ Zhao, HL Wong, J Cai, L Peng… - International journal of …, 2014 - Taylor & Francis
Although many agents have therapeutic potentials for central nervous system (CNS)
diseases, few of these agents have been clinically used because of the brain barriers. As the …
diseases, few of these agents have been clinically used because of the brain barriers. As the …