Mechanisms and functions of inflammasomes
Recent studies have offered a glimpse into the sophisticated mechanisms by which
inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18 …
inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18 …
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
CA Dinarello, A Simon… - Nature reviews Drug …, 2012 - nature.com
Abstract Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …
Systemic amyloidosis
Tissue deposition of protein fibrils causes a group of rare diseases called systemic
amyloidoses. This Seminar focuses on changes in their epidemiology, the current approach …
amyloidoses. This Seminar focuses on changes in their epidemiology, the current approach …
The NLRP3 inflammasome: contributions to inflammation-related diseases
Y Chen, X Ye, G Escames, W Lei, X Zhang, M Li… - Cellular & molecular …, 2023 - Springer
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …
innate immune responses by activating caspase-1 and the inflammatory cytokines …
NLRP3 inflammasome in neurological diseases, from functions to therapies
L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …
Treating inflammation by blocking interleukin-1 in humans
CA Dinarello, JWM van der Meer - Seminars in immunology, 2013 - Elsevier
IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …
The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory …
Background The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases,
including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor …
including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor …
Anakinra therapy for non-cancer inflammatory diseases
G Cavalli, CA Dinarello - Frontiers in pharmacology, 2018 - frontiersin.org
Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-
1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory …
1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory …
Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease
Excessive activation of microglia and subsequent release of proinflammatory cytokines play
a crucial role in neuroinflammation and neurodegeneration in Parkinson's disease (PD) …
a crucial role in neuroinflammation and neurodegeneration in Parkinson's disease (PD) …
Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review
Objective To evaluate the response to treatment of autoinflammatory diseases from an
international registry and an up-to-date literature review. Methods The response to treatment …
international registry and an up-to-date literature review. Methods The response to treatment …