A paradigm shift in translational psychiatry through rodent neuroethology

Y Shemesh, A Chen - Molecular psychiatry, 2023 - nature.com
Mental disorders are a significant cause of disability worldwide. They profoundly affect
individuals' well-being and impose a substantial financial burden on societies and …

[HTML][HTML] Social functioning in major depressive disorder

A Kupferberg, L Bicks, G Hasler - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
Depression is associated with social risk factors, social impairments and poor social
functioning. This paper gives an overview of these social aspects using the NIMH Research …

Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus

A Kos, JP Lopez, J Bordes, C De Donno, J Dine… - Science …, 2023 - science.org
Adverse events in early life can modulate the response to additional stressors later in life
and increase the risk of develo** psychiatric disorders. The underlying molecular …

[HTML][HTML] Correlated neural activity and encoding of behavior across brains of socially interacting animals

L Kingsbury, S Huang, J Wang, K Gu, P Golshani… - Cell, 2019 - cell.com
Social interactions involve complex decision-making tasks that are shaped by dynamic,
mutual feedback between participants. An open question is whether and how emergent …

A circuit from hippocampal CA2 to lateral septum disinhibits social aggression

F Leroy, J Park, A Asok, DH Brann, T Meira, LM Boyle… - Nature, 2018 - nature.com
Although the hippocampus is known to be important for declarative memory, it is less clear
how hippocampal output regulates motivated behaviours, such as social aggression. Here …

Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice

Y Sofer, N Zilkha, E Gimpel, S Wagner… - Nature …, 2024 - nature.com
In nature, both males and females engage in competitive aggressive interactions to resolve
social conflicts, yet the behavioral principles guiding such interactions and their underlying …

Ecological validity of social interaction tests in rats and mice

K Kondrakiewicz, M Kostecki… - Genes, Brain and …, 2019 - Wiley Online Library
Different rat and mouse models are used in studies of social interactions. Simple behavioral
measures, which are commonly used in the laboratory, allow to perform relatively short …

Neural systems that facilitate the representation of social rank

MF Dwortz, JP Curley, KM Tye… - … Transactions of the …, 2022 - royalsocietypublishing.org
Across species, animals organize into social dominance hierarchies that serve to decrease
aggression and facilitate survival of the group. Neuroscientists have adopted several model …

Social dominance mediates behavioral adaptation to chronic stress in a sex-specific manner

S Karamihalev, E Brivio, C Flachskamm, R Stoffel… - Elife, 2020 - elifesciences.org
Sex differences and social context independently contribute to the development of stress-
related disorders. However, less is known about how their interplay might influence behavior …

Distinct immune and transcriptomic profiles in dominant versus subordinate males in mouse social hierarchies

W Lee, TM Milewski, MF Dwortz, RL Young… - Brain, Behavior, and …, 2022 - Elsevier
Social status is a critical factor determining health outcomes in human and nonhuman social
species. In social hierarchies with reproductive skew, individuals compete to monopolize …