The still‐evolving mechanostat hypothesis for bones inserts tissue‐level realities into the
former knowledge gap between bone's organ‐level and cell‐level realities. It concerns load …

The essentiality of zinc in humans was established in 1963. During the past 50 y,
tremendous advances in both clinical and basic sciences of zinc metabolism in humans …

The Female Athlete Triad is a medical condition often observed in physically active girls and
women, and involves three components:(1) low energy availability with or without …

Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue
engineering due to their compositional similarities to bone mineral and excellent …

Since the original somatomedin hypothesis was conceived, a number of important
discoveries have allowed investigators to modify the concept. Originally somatic growth was …

Abstract By 1892, Julius Wolff and others realized that mechanical loads can affect bone
architecture in living beings, but the mechanisms responsible for this effect were unknown …

The inhibition of growth is a cardinal symptom of zinc deficiency. In animals fed a zinc-
inadequate diet, both food intake and growth are reduced within 4–5 d. Despite the …

Abstract GH and IGF-I are important regulators of bone homeostasis and are central to the
achievement of normal longitudinal bone growth and bone mass. Although GH may act …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Aim—To contribute to the debate about whether growth hormone (GH) and insulin-like
growth factor 1 (IGF-1) act independently on the growth process. Methods—To describe …