Transition-metal-catalyzed cross-couplings through carbene migratory insertion

Y **a, D Qiu, J Wang - Chemical reviews, 2017 - ACS Publications
Transition-metal-catalyzed cross-coupling reactions have been well-established as
indispensable tools in modern organic synthesis. One of the major research goals in cross …

Taming hazardous chemistry by continuous flow technology

M Movsisyan, EIP Delbeke, J Berton… - Chemical Society …, 2016 - pubs.rsc.org
Over the last two decades, flow technologies have become increasingly popular in the field
of organic chemistry, offering solutions for engineering and/or chemical problems. Flow …

Flow chemistry: recent developments in the synthesis of pharmaceutical products

R Porta, M Benaglia, A Puglisi - Organic Process Research & …, 2016 - ACS Publications
Recently, application of the flow technologies for the preparation of fine chemicals, such as
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …

Deciphering the chameleonic chemistry of allenols: breaking the taboo of a onetime esoteric functionality

JM Alonso, P Almendros - Chemical Reviews, 2021 - ACS Publications
The allene functionality has participated in one of the most exciting voyages in organic
chemistry, from chemical curiosities to a recurring building block in modern organic …

[HTML][HTML] Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis

F Fanelli, G Parisi, L Degennaro… - Beilstein Journal of …, 2017 - beilstein-journals.org
Microreactor technology and flow chemistry could play an important role in the development
of green and sustainable synthetic processes. In this review, some recent relevant examples …

Recent advances in catalytic asymmetric synthesis of allenes

WD Chu, Y Zhang, J Wang - Catalysis Science & Technology, 2017 - pubs.rsc.org
Allene moieties with axial chirality are featured in many natural products with biological
activities. They also serve as unique building blocks in organic synthesis and as chiral …

Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2)–C(sp3) Cross‐Couplings in Flow

F Lima, MA Kabeshov, DN Tran… - Angewandte …, 2016 - Wiley Online Library
We report herein a new method for the photoredox activation of boronic esters. Using these
reagents, an efficient and high‐throughput continuous flow process was developed to …

Nickel-catalyzed asymmetric propargylation for the synthesis of axially chiral 1, 3-disubstituted allenes

X Xu, M Wang, L Peng, C Guo - Journal of the American Chemical …, 2022 - ACS Publications
The general enantioselective catalytic synthesis of axially chiral 1, 3-disubstituted allenes
from readily available racemic propargylic alcohol derivatives remains a long-standing …

Pushing the boundaries of C–H bond functionalization chemistry using flow technology

S Govaerts, A Nyuchev, T Noel - Journal of Flow Chemistry, 2020 - Springer
C–H functionalization chemistry is one of the most vibrant research areas within synthetic
organic chemistry. While most researchers focus on the development of small-scale batch …

Enabling technologies for the future of chemical synthesis

DE Fitzpatrick, C Battilocchio, SV Ley - ACS central science, 2016 - ACS Publications
Technology is evolving at breakneck pace, changing the way we communicate, travel, find
out information, and live our lives. Yet chemistry as a science has been slower to adapt to …