Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

In recent years, the traditional view of the hemostatic system as being regulated by a
coagulation factor cascade coupled with platelet activation has been increasingly …

Background Coronavirus induced disease 2019 (COVID-19) can be complicated by severe
organ damage leading to dysfunction of the lungs and other organs. The processes that …

Cardiovascular diseases are a leading cause of mortality and morbidity worldwide.
Neutrophils are a component of the innate immune system which protect against pathogen …

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection and is associated with high morbidity and mortality. Circulating …

Heparins represent one of the most frequently used pharmacotherapeutics. Discovered
around 1926, routine clinical anticoagulant use of heparin was initiated only after the …

The components and reactions of the fibrinolysis system are well understood. The pathway
has fewer reactants and interactions than coagulation, but the generation of a complete …

Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically
manifests as swelling and pain in the lower limbs. The most serious clinical complication of …

The protection exerted by neutrophils against invading microbes is partially mediated via the
generation of neutrophil extracellular traps (NETs). In sterile conditions NETs are damaging …

Background: Patients with sepsis commonly exhibit a hypercoagulability with high risk of
venous thromboembolism (VTE). Neutrophil extracellular traps (NETs) are found to trigger …