Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

Infections of antibiotic-resistant pathogens pose an ever-increasing threat to mankind. The
investigation of novel approaches for tackling the antimicrobial resistance crisis must be part …

Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-
negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ …

Multidrug-resistant (MDR) bacterial infections are a serious threat to public health. Among
the most alarming resistance trends is the rapid rise in the number and diversity of β …

Resistance to available antibiotics in pathogenic bacteria is currently a global challenge
since the number of strains that are resistant to multiple types of antibiotics has increased …

Infections caused by resistant bacteria are nowadays too common, and some pathogens
have even become resistant to multiple types of antibiotics, in which case few or even no …

Limited treatment options exist to combat infections caused by multidrug-resistant (MDR)
Gram-negative bacteria possessing broad-spectrum β-lactamases. The design of novel β …

There is urgent need for new therapeutic strategies to fight the global threat of antibiotic
resistance. The focus of this Perspective is on chemical agents that target the most common …

Carbon dots are small carbon nanoparticles with intrinsic photoluminescence. Because of
the advantages such as good biocompatibility and water dispersity, many researchers have …