Covering: 1953 to September 2005Daptomycin (Cubicin®) is a lipopeptide antibiotic
approved in the USA in 2003 for the treatment of skin and skin structure infections caused by …

Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous
bacteria responsible for producing most natural antibiotics used in human and veterinary …

The calcium-dependent antibiotic (CDA), from Streptomyces coelicolor, is an acidic
lipopeptide comprising an N-terminal 2, 3-epoxyhexanoyl fatty acid side chain and several …

Four Streptomyces species have been described as the causal agents of scab disease,
which affects economically important root and tuber crops worldwide. These species …

Streptomyces, and related genera of Actinobacteria, are renowned for their ability to produce
antibiotics and other bioactive natural products with a wide range of applications in medicine …

During the past two decades, the technological progress of whole-genome sequencing
(WGS) had changed the fields of Environmental Microbiology and Biotechnology, and …

The eubacterial species Streptomyces coelicolor proceeds through a complex growth cycle
in which morphological differentiation/development is associated with a transition from …

The ActII-ORF4 protein has been characterized as a DNA-binding protein that positively
regulates the transcription of the actinorhodin biosynthetic genes. The target regions for the …

Streptomycetes are the most important bacterial producers of bioactive secondary
metabolites such as antibiotics or cytostatics. Due to the emerging resistance of pathogenic …