Traditionally, multiple sclerosis has been categorised by distinct clinical descriptors—
relapsing-remitting, secondary progressive, and primary progressive—for patient care …

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …

Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet
the underlying mechanisms remain unclear. By dissecting the neuronal inflammatory stress …

Oligodendrocyte loss in neurological disease leaves axons vulnerable to damage and
degeneration, and activity-dependent myelination may represent an endogenous …

Selectively labeling cells with damaged membranes is needed not only for identifying dead
cells in culture, but also for imaging membrane barrier dysfunction in pathologies in vivo …

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …

Whether, to what extent, and how the axons in the central nervous system (CNS) can
withstand sudden mechanical impacts remain unclear. By using a microfluidic device to …

Axonal degeneration determines the clinical outcome of multiple sclerosis and is thought to
result from exposure of denuded axons to immune-mediated damage. Therefore, myelin is …

SARM1 is an inducible NAD+ hydrolase that triggers axon loss and neuronal cell death in
the injured and diseased nervous system. While SARM1 activation and enzyme function are …

Oligodendrocyte progenitor cells (OPCs) are the most proliferative and dispersed population
of progenitor cells in the adult central nervous system, which allows these cells to rapidly …