Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

X Tong, R Tang, M **ao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

[HTML][HTML] Pyroptosis in inflammatory diseases and cancer

Z Rao, Y Zhu, P Yang, Z Chen, Y **a, C Qiao, W Liu… - Theranostics, 2022 - ncbi.nlm.nih.gov
Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

ZIF‐8 nanoparticles evoke pyroptosis for high‐efficiency cancer immunotherapy

B Ding, H Chen, J Tan, Q Meng… - Angewandte Chemie …, 2023 - Wiley Online Library
Although zeolitic imidazolate framework‐8 (ZIF‐8) has been applied in various tumor
therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that …

A pyroptosis nanotuner for cancer therapy

B Chen, Y Yan, Y Yang, G Cao, X Wang… - Nature …, 2022 - nature.com
Pyroptosis is a gasdermin-mediated programmed necrosis that occurs via membrane
perforation and that can be exploited for biomedical applications in cancer therapy …

The uptake of metal–organic frameworks: A journey into the cell

E Linnane, S Haddad, F Melle, Z Mei… - Chemical Society …, 2022 - pubs.rsc.org
The application of metal–organic frameworks (MOFs) in drug delivery has advanced rapidly
over the past decade, showing huge progress in the development of novel systems …

Mitigating metal-organic framework (MOF) toxicity for biomedical applications

P Wiśniewska, J Haponiuk, MR Saeb, N Rabiee… - Chemical Engineering …, 2023 - Elsevier
Metal-organic frameworks (MOFs) are a novel class of crystalline porous materials,
consisting of metal ions and organic linkers. These hybrid materials possess exceptional …

Biomineralized two‐enzyme nanoparticles regulate tumor glycometabolism inducing tumor cell pyroptosis and robust antitumor immunotherapy

S Zhang, Y Zhang, Y Feng, J Wu, Y Hu, L Lin… - Advanced …, 2022 - Wiley Online Library
Currently, immune checkpoint therapy combined with chemotherapy and radiotherapy is a
useful strategy for improving immunotherapy's therapeutic efficacy. However, chemotherapy …

Biodegradable Ca2+ Nanomodulators Activate Pyroptosis through Mitochondrial Ca2+ Overload for Cancer Immunotherapy

P Zheng, B Ding, G Zhu, C Li, J Lin - Angewandte Chemie, 2022 - Wiley Online Library
Pyroptosis provides a new direction and broad prospects for cancer immunotherapy.
However, the development of a nanoplatform as a pyroptosis inducer is limited, and the …

Metallodrugs in cancer nanomedicine

Q Peña, A Wang, O Zaremba, Y Shi… - Chemical society …, 2022 - pubs.rsc.org
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

A carbonic anhydrase IX (CAIX)‐anchored rhenium (I) photosensitizer evokes pyroptosis for enhanced anti‐tumor immunity

X Su, WJ Wang, Q Cao, H Zhang, B Liu… - Angewandte Chemie …, 2022 - Wiley Online Library
An ideal cancer treatment should not only destroy primary tumors but also improve the
immunogenicity of the tumor microenvironment to achieve a satisfactory anti‐tumor immune …