The transcription factor NF-κB is a critical regulator of immune and inflammatory responses.
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …

Cancer is a group of cells that malignantly grow and proliferate uncontrollably. At present,
treatment modes for cancer mainly comprise surgery, chemotherapy, radiotherapy …

Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …

Cancer is often characterised by the presence of hypoxia and inflammation. Paramount to
the mechanisms controlling cellular responses under such stress stimuli, are the …

The Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate-and Fe (II)-dependent
oxygenases. KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that …

Many biologically significant processes, such as cell differentiation and cell cycle
progression, gene transcription and DNA replication, chromosome stability and epigenetic …

Protein arginine methyltransferases (PRMTs) are a family of enzymes that can methylate
arginine residues on histones and other proteins. PRMTs play a crucial role in influencing …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

A fundamental property of cells of the innate immune system is their ability to elicit a
transcriptional response to a microbial stimulus or danger signal with a high degree of cell …

Protein lysine methylation is a critical and dynamic post-translational modification that can
regulate protein stability and function. This post-translational modification is regulated by …