[HTML][HTML] Focus: the aging brain: amyloid-beta Alzheimer targets—protein processing, lipid rafts, and amyloid-beta pores
M LaFontaine, M Cumbay - The Yale journal of biology and …, 2016 - ncbi.nlm.nih.gov
Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious
in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen …
in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen …
Designing peptide nanoparticles for efficient brain delivery
The targeted delivery of therapeutic compounds to the brain is arguably the most significant
open problem in drug delivery today. Nanoparticles (NPs) based on peptides and designed …
open problem in drug delivery today. Nanoparticles (NPs) based on peptides and designed …
Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer's disease
K Jovanovic, CJ Chetty, T Khumalo… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: The 37/67 kDa high-affinity laminin receptor (laminin receptor precursor/laminin
receptor, LRP/LR) is a multi-faceted cellular receptor. It plays a vital role in the malignancy of …
receptor, LRP/LR) is a multi-faceted cellular receptor. It plays a vital role in the malignancy of …
Anti-LRP/LR-specific antibody IgG1-iS18 significantly reduces adhesion and invasion of metastatic lung, cervix, colon and prostate cancer cells
A Omar, U Reusch, S Knackmuss, M Little… - Journal of molecular …, 2012 - Elsevier
The 37-kDa/67-kDa laminin receptor [laminin receptor precursor/high-affinity laminin
receptor (LRP/LR)] is thought to play a major role in invasion and adhesion, key components …
receptor (LRP/LR)] is thought to play a major role in invasion and adhesion, key components …
67 laminin receptor promotes the malignant potential of tumour cells up-regulating lysyl oxidase-like 2 expression in cholangiocarcinoma
J Xu, D Li, X Li, Z Liu, T Li, P Jiang, Q He, F Tian… - Digestive and Liver …, 2014 - Elsevier
Abstract Background 67 laminin receptor (67LR) plays an important role in the invasion and
metastasis of cholangiocarcinoma, but its mechanism remains unclear. Aims We …
metastasis of cholangiocarcinoma, but its mechanism remains unclear. Aims We …
Downregulation of the non-integrin laminin receptor reduces cellular viability by inducing apoptosis in lung and cervical cancer cells
K Moodley, SFT Weiss - PloS one, 2013 - journals.plos.org
The non-integrin laminin receptor, here designated the 37-kDa/67-kDa laminin receptor
(LRP/LR), is involved in many physiologically relevant processes, as well as numerous …
(LRP/LR), is involved in many physiologically relevant processes, as well as numerous …
Proteomics approach to identify the interacting partners of cellular prion protein and characterization of Rab7a interaction in neuronal cells
S Zafar, N von Ahsen, M Oellerich, I Zerr… - Journal of proteome …, 2011 - ACS Publications
The present study was undertaken to identify proteins interacting with PrPC that could
provide new insights into its physiological functions and pathological role. Human PrPC was …
provide new insights into its physiological functions and pathological role. Human PrPC was …
A Bacteria Deriving Peptide Modified Dendrigraft Poly-l-lysines (DGL) Self-Assembling Nanoplatform for Targeted Gene Delivery
Achieving effective gene therapy for glioma depends on gene delivery systems. The gene
delivery system should be able to cross the blood–brain barrier (BBB) and further target …
delivery system should be able to cross the blood–brain barrier (BBB) and further target …
Knockdown of LRP/LR induces apoptosis in breast and oesophageal cancer cells
T Khumalo, E Ferreira, K Jovanovic, RB Veale… - PloS one, 2015 - journals.plos.org
Cancer is a global burden due to high incidence and mortality rates and is ranked the
second most diagnosed disease amongst non-communicable diseases in South Africa. A …
second most diagnosed disease amongst non-communicable diseases in South Africa. A …
Targeting prion protein interactions in cancer
In recent years, prion protein (PrPC) has been considered as a promising target molecule for
cancer therapies, due its direct or indirect participation in tumor growth, metastasis, and …
cancer therapies, due its direct or indirect participation in tumor growth, metastasis, and …