Abstract Structure and function are highly correlated in the vertebrate retina, a sensory tissue
that is organized into cell layers with microcircuits working in parallel and together to encode …

Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular
components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes …

Degenerative retinal disorders are a diverse family of diseases commonly leading to
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …

Alternative splicing of nucleoredoxin-like 1 (Nxnl1) results in 2 isoforms of the rod-derived
cone viability factor. The truncated form (RdCVF) is a thioredoxin-like protein secreted by …

Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a
technological breakthrough in the diagnosis, treatment, and follow-up of many retinal …

Although an increasing number of disease genes have been identified, the exact cellular
mechanisms of retinitis pigmentosa (RP) remain largely unclear. Retinal organoids (ROs) …

Retinitis pigmentosa (RP), a family of inherited disorders characterized by progressive
photoreceptor death, is a leading cause of blindness with no available cure. Despite the …

Retinitis pigmentosa is a group of hereditary retinal dystrophies that normally result in
photoreceptor cell death and vision loss both in animal models and in affected patients. The …

Accurate quantification of retinal layer thicknesses in mice as seen on optical coherence
tomography (OCT) is crucial for the study of numerous ocular and neurological diseases …