The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

Macrophages are now considered to be important players in various inflammatory diseases
as well as tumor progression. Emerging evidence reveals that macrophage metabolic …

The glyoxylate shunt is a metabolic pathway of bacteria, fungi, and plants used to assimilate
even-chain fatty acids (FAs) and has been implicated in persistence of Mycobacterium …

Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that predominantly affects
the alveolar macrophages in the respiratory tract. Upon infection, the activation of TLR2 and …

Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of
drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control …

Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of
Mycobacterium tuberculosis. Herein, we report that ICLs form a covalent adduct with …

Biofilm formation by Mycobacterium fortuitum causes serious threats to human health due to
its increased contribution to nosocomial infections. In this study, the first comprehensive …

Antibiotics can stimulate or depress gene expression in bacteria. The analysis of
transcriptional responses of Mycobacterium to antimycobacterial compounds has improved …

The antimicrobial role of itaconic acid (ITA) has been recently discovered in mammalian
cells. In our previous studies, we discovered that marine molluscs biosynthesise substantial …

It is well-established that mitochondria are the powerhouses of the cell, producing
adenosine triphosphate (ATP), the universal energy currency. However, the most significant …