Glioblastoma therapy: Past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

[HTML][HTML] Advancements in glioma care: Focus on emerging neurosurgical techniques

M De Simone, V Conti, G Palermo, L De Maria… - Biomedicines, 2023 - mdpi.com
Background: Despite significant advances in understanding the molecular pathways of
glioma, translating this knowledge into effective long-term solutions remains a challenge …

Nanoparticle-based combinational strategies for overcoming the blood-brain barrier and blood-tumor barrier

SH Lim, GT Yee, D Khang - International Journal of Nanomedicine, 2024 - Taylor & Francis
The blood-brain barrier (BBB) and blood-tumor barrier (BTB) pose substantial challenges to
efficacious drug delivery for glioblastoma multiforme (GBM), a primary brain tumor with poor …

[HTML][HTML] Preclinical models and technologies in Glioblastoma Research: evolution, current state, and future avenues

H Slika, Z Karimov, P Alimonti, T Abou-Mrad… - International journal of …, 2023 - mdpi.com
Glioblastoma is the most common malignant primary central nervous system tumor and one
of the most debilitating cancers. The prognosis of patients with glioblastoma remains poor …

Peritumoral brain zone in glioblastoma: Biological, clinical and mechanical features

A Ballestín, D Armocida, V Ribecco… - Frontiers in …, 2024 - frontiersin.org
Glioblastoma is a highly aggressive and invasive tumor that affects the central nervous
system (CNS). With a five-year survival rate of only 6.9% and a median survival time of eight …

Sonodynamic therapy and magnetic resonance-guided focused ultrasound: New therapeutic strategy in glioblastoma

L Bonosi, S Marino, UE Benigno, S Musso… - Journal of neuro …, 2023 - Springer
Glioblastoma (GB) is one of the most aggressive and difficult-to-treat brain tumors, with a
poor prognosis and limited treatment options. In recent years, sonodynamic therapy (SDT) …

A Roadmap of CAR-T-cell therapy in glioblastoma: Challenges and future perspectives

M Montoya, M Gallus, S Phyu, J Haegelin, J de Groot… - Cells, 2024 - mdpi.com
Glioblastoma (GBM) is the most common primary malignant brain tumor, with a median
overall survival of less than 2 years and a nearly 100% mortality rate under standard therapy …

A phase I clinical trial of sonodynamic therapy combined with temozolomide in the treatment of recurrent glioblastoma

B Zha, J Yang, Q Dang, P Li, S Shi, J Wu, H Cui… - Journal of neuro …, 2023 - Springer
Purpose The prognosis of recurrent glioblastoma (rGBM) is poor, and there is currently no
effective treatment strategy. Sonodynamic therapy (SDT) is a new method for cancer …

Long-acting therapeutic delivery systems for the treatment of gliomas

S Padmakumar, MM Amiji - Advanced drug delivery reviews, 2023 - Elsevier
Despite the emergence of cutting-edge therapeutic strategies and tremendous progress in
research, a complete cure of glioma remains elusive. The heterogenous nature of tumor …

[HTML][HTML] Current clinical investigations of focused ultrasound blood-brain barrier disruption: a review

PG Durham, A Butnariu, R Alghorazi, G Pinton… - …, 2024 - Elsevier
The blood-brain barrier (BBB) presents a formidable challenge in delivering therapeutic
agents to the central nervous system. Ultrasound-mediated BBB disruption has emerged as …