Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

BACKGROUND The embryo implantation process is crucial for the correct establishment
and progress of pregnancy. During implantation, the blastocyst trophectoderm cells attach to …

Proper development of the placenta is vital for pregnancy success. The placenta regulates
exchange of nutrients and gases between maternal and fetal blood and produces hormones …

The trophectoderm layer of the blastocyst-stage embryo is the precursor for all trophoblast
cells in the placenta. Human trophoblast stem (TS) cells have emerged as an attractive tool …

BACKGROUND Villous cytotrophoblast (vCTB) is a precursor cell population that supports
the development of syncytiotrophoblast (vSTB), the high surface area barrier epithelium of …

Appropriate human trophoblast lineage specification and differentiation is crucial for the
establishment of normal placentation and maintenance of pregnancy. However, due to the …

During early mammalian embryonic development, trophoblast cells play an essential role in
establishing cell–cell interactions at the maternal–fetal interface to ensure a successful …

The human placenta is a poorly-understood organ, but one that is critical for proper
development and growth of the fetus in-utero. The epithelial cell type that contributes to …

Preeclampsia (PE) is a pregnancy-specific hypertensive disorder, affecting up to 10% of
pregnancies worldwide. The primary etiology is considered to be abnormal development …

Acting as the primary link between mother and fetus, the placenta is involved in regulating
nutrient, oxygen, and waste exchange; thus, healthy placental development is crucial for a …