The p38 MAPK pathway is well known for its role in transducing stress signals from the
environment. Many key players and regulatory mechanisms of this signaling cascade have …

Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival.
Cellular adaptation mechanisms include modification of certain aspects of cell physiology …

Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular
protozoan parasite that resides inside a parasitophorous vacuole. During infection …

Polyamines are small organic polycations that are absolutely required for cell growth and
proliferation; yet the basis for this requirement is mostly unknown. Here, we combined a …

Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has been
implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and …

Intuitive visualization of data and results is very important in genomics, especially when
many conditions are to be analyzed and compared. Heat-maps have proven very useful for …

Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells
from solid tumours together with their native microenvironment. They offer a low throughput …

Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to
chemotherapy is poorly understood. In this study, we investigate the initial signaling …

The stress-activated protein kinases c-Jun N-terminal kinase (JNK) and p38 are important
players in cell-fate decisions in response to environmental stress signals. Crosstalk …

The kinase Mnk2 is a substrate of the MAPK pathway and phosphorylates the translation
initiation factor eIF4E. In humans, MKNK2, the gene encoding for Mnk2, is alternatively …