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Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
[HTML][HTML] Hepatitis B virus-associated hepatocellular carcinoma
Hepatitis B virus (HBV) is DNA-based virus, member of the Hepadnaviridae family, which
can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected …
can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected …
Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma
Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead
to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer …
to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer …
Mechanisms of HBV-induced hepatocellular carcinoma
M Levrero, J Zucman-Rossi - Journal of hepatology, 2016 - Elsevier
Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
HIF transcription factors, inflammation, and immunity
The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible
factor (HIF) transcription factors; these play an integral role in the metabolic changes that …
factor (HIF) transcription factors; these play an integral role in the metabolic changes that …
Human viral oncogenesis: a cancer hallmarks analysis
Approximately 12% of all human cancers are caused by oncoviruses. Human viral
oncogenesis is complex, and only a small percentage of the infected individuals develop …
oncogenesis is complex, and only a small percentage of the infected individuals develop …
[HTML][HTML] Hepatitis B viral protein HBx and the molecular mechanisms modulating the hallmarks of hepatocellular carcinoma: a comprehensive review
With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the
most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X …
most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X …
[HTML][HTML] The role of HIF in immunity and inflammation
AF McGettrick, LAJ O'Neill - Cell metabolism, 2020 - cell.com
HIF is a transcription factor that plays an essential role in the cellular response to low
oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In …
oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In …
Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma
A Arzumanyan, HM Reis, MA Feitelson - Nature Reviews Cancer, 2013 - nature.com
Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …
Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm
COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of
2019 and was rapidly spread in most countries. This respiratory virus has different symptoms …
2019 and was rapidly spread in most countries. This respiratory virus has different symptoms …