Going beyond primary motor cortex to improve brain–computer interfaces

JA Gallego, TR Makin, SD McDougle - Trends in neurosciences, 2022 - cell.com
Brain–computer interfaces (BCIs) for movement restoration typically decode the user's intent
from neural activity in their primary motor cortex (M1) and use this information to enable …

Preparatory activity and the expansive null-space

MM Churchland, KV Shenoy - Nature Reviews Neuroscience, 2024 - nature.com
The study of the cortical control of movement experienced a conceptual shift over recent
decades, as the basic currency of understanding shifted from single-neuron tuning towards …

Mice alternate between discrete strategies during perceptual decision-making

ZC Ashwood, NA Roy, IR Stone… - Nature …, 2022 - nature.com
Classical models of perceptual decision-making assume that subjects use a single,
consistent strategy to form decisions, or that decision-making strategies evolve slowly over …

Slow drift of neural activity as a signature of impulsivity in macaque visual and prefrontal cortex

BR Cowley, AC Snyder, K Acar, RC Williamson… - Neuron, 2020 - cell.com
An animal's decision depends not only on incoming sensory evidence but also on its
fluctuating internal state. This state embodies multiple cognitive factors, such as arousal and …

Contribution of behavioural variability to representational drift

S Sadeh, C Clopath - Elife, 2022 - elifesciences.org
Neuronal responses to similar stimuli change dynamically over time, raising the question of
how internal representations can provide a stable substrate for neural coding. Recent work …

Learning leaves a memory trace in motor cortex

DM Losey, JA Hennig, ER Oby, MD Golub, PT Sadtler… - Current Biology, 2024 - cell.com
How are we able to learn new behaviors without disrupting previously learned ones? To
understand how the brain achieves this, we used a brain-computer interface (BCI) learning …

A neural basis of choking under pressure

AL Smoulder, PJ Marino, ER Oby, SE Snyder, H Miyata… - Neuron, 2024 - cell.com
Incentives tend to drive improvements in performance. But when incentives get too high, we
can" choke under pressure" and underperform right when it matters most. What neural …

How learning unfolds in the brain: toward an optimization view

JA Hennig, ER Oby, DM Losey, AP Batista, MY Byron… - Neuron, 2021 - cell.com
How do changes in the brain lead to learning? To answer this question, consider an artificial
neural network (ANN), where learning proceeds by optimizing a given objective or cost …

Fundamental processes in sensorimotor learning: Reasoning, refinement, and retrieval

JS Tsay, HE Kim, SD McDougle, JA Taylor, A Haith… - Elife, 2024 - elifesciences.org
Motor learning is often viewed as a unitary process that operates outside of conscious
awareness. This perspective has led to the development of sophisticated models designed …

Nonlinear manifolds underlie neural population activity during behaviour

C Fortunato, J Bennasar-Vázquez, J Park, JC Chang… - …, 2024 - pmc.ncbi.nlm.nih.gov
There is rich variety in the activity of single neurons recorded during behaviour. Yet, these
diverse single neuron responses can be well described by relatively few patterns of neural …