Guidelines for experimental models of myocardial ischemia and infarction

ML Lindsey, R Bolli, JM Canty Jr… - American Journal …, 2018 - journals.physiology.org
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

HE Bøtker, D Hausenloy, I Andreadou… - Basic research in …, 2018 - Springer
The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Functional polymer microspheres

H Kawaguchi - Progress in polymer science, 2000 - Elsevier
Functional particles are prepared directly by heterogeneous polymerization, eg emulsion
polymerization and dispersion polymerization. Modification of existing particles is another …

Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of …

E Van Belle, B Witzenbichler, D Chen, M Silver… - Circulation, 1998 - Am Heart Assoc
Background—Scatter factor/hepatocyte growth factor (SF/HGF) is a pleiotropic growth factor
that stimulates proliferation and migration of endothelial cells (ECs) via the c-Met receptor …

Reperfusion induces myocardial apoptotic cell death

ZQ Zhao, M Nakamura, NP Wang… - Cardiovascular …, 2000 - academic.oup.com
Objective: The purpose of the present study was to investigate whether apoptosis is
triggered during ischemia (I) and reperfusion (R) and whether I/R-induced apoptosis is …

Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic …

P Kleinbongard, HR Lieder, A Skyschally… - Basic research in …, 2022 - Springer
The translation of successful preclinical and clinical proof-of-concept studies on
cardioprotection to the benefit of patients with reperfused acute myocardial infarction has …

Coronary circulation in dogs with an experimental decrease in aortic compliance

H Watanabe, S Ohtsuka, M Kakihana… - Journal of the American …, 1993 - Elsevier
Objectives. This study was designed to investigate the effects of decreased aortic
compliance on the coronary circulation. Background. A decrease in aortic compliance due to …

Across-species transfer of protection by remote ischemic preconditioning with species-specific myocardial signal transduction by reperfusion injury salvage kinase and …

A Skyschally, S Gent, G Amanakis, C Schulte… - Circulation …, 2015 - Am Heart Assoc
Rationale: Reduction of myocardial infarct size by remote ischemic preconditioning (RIPC),
that is, cycles of ischemia/reperfusion in an organ remote from the heart before sustained …

Left ventricular support by Catheter-Mountedaxial flow pump reduces infarct size

B Meyns, J Stolinski, V Leunens, E Verbeken… - Journal of the American …, 2003 - jacc.org
Objectives: We sought to investigate the effect of a catheter-mounted microaxial blood pump
(Impella, Aachen, Germany) on myocardial infarct size. Background: The small rotary blood …

Coronary no reflow

BG Schwartz, RA Kloner - Journal of molecular and cellular cardiology, 2012 - Elsevier
The no-reflow phenomenon has been studied extensively in the basic science laboratory
and has entered the clinical arena. No-reflow, which develops largely within the first 2h of …