Osteoimmunology: the conceptual framework unifying the immune and skeletal systems
K Okamoto, T Nakashima, M Shinohara… - Physiological …, 2017 - journals.physiology.org
The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
The mechanisms of T cell selection in the thymus
H Takaba, H Takayanagi - Trends in immunology, 2017 - cell.com
T cells undergo positive and negative selection in the thymic cortex and medulla,
respectively. A promiscuous expression of a wide array of self-antigens in the thymus is …
respectively. A promiscuous expression of a wide array of self-antigens in the thymus is …
Regulatory T cell development
PA Savage, DEJ Klawon… - Annual review of …, 2020 - annualreviews.org
Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development
The thymus is responsible for generating a diverse yet self-tolerant pool of T cells. Although
the thymic medulla consists mostly of develo** and mature AIRE+ epithelial cells, recent …
the thymic medulla consists mostly of develo** and mature AIRE+ epithelial cells, recent …
Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation
L Klein, EA Robey, CS Hsieh - Nature Reviews Immunology, 2019 - nature.com
The diversion of MHC class II-restricted thymocytes into the regulatory T (Treg) cell lineage
is driven by intrathymic encounter of agonist self-antigens in a similar manner to the clonal …
is driven by intrathymic encounter of agonist self-antigens in a similar manner to the clonal …
Fezf2 orchestrates a thymic program of self-antigen expression for immune tolerance
Self-tolerance to immune reactions is established via promiscuous expression of tissue-
restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), leading to the …
restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), leading to the …
Thymic epithelial cells
Intrathymic T cell development is a complex process that depends upon continuous
guidance from thymus stromal cell microenvironments. The thymic epithelium within the …
guidance from thymus stromal cell microenvironments. The thymic epithelium within the …
T-cell tolerance: central and peripheral
Y **ng, KA Hogquist - Cold Spring Harbor perspectives …, 2012 - cshperspectives.cshlp.org
Somatic recombination of TCR genes in immature thymocytes results in some cells with
useful TCR specificities, but also many with useless or potentially self-reactive specificities …
useful TCR specificities, but also many with useless or potentially self-reactive specificities …
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia
SN Sansom, N Shikama-Dorn, S Zhanybekova… - Genome …, 2014 - genome.cshlp.org
Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for
generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for …
generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for …
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
Naturally arising CD25+ CD4+ regulatory T (Treg) cells, most of which are produced by the
normal thymus as a functionally mature T‐cell subpopulation, play key roles in the …
normal thymus as a functionally mature T‐cell subpopulation, play key roles in the …