[HTML][HTML] Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting

C Baudouin, P Aragona, EM Messmer, A Tomlinson… - The ocular …, 2013 - Elsevier
Dry eye disease (DED), a multifactorial disease of the tears and ocular surface, is common
and has a significant impact on quality of life. Reduced aqueous tear flow and/or increased …

[HTML][HTML] Age-related changes in the kinetics of human lenses: prevention of the cataract

N Pescosolido, A Barbato, R Giannotti… - International Journal …, 2016 - ncbi.nlm.nih.gov
The crystalline lens is a transparent, biconvex structure in the eye that, along with the
cornea, helps to refract light to be focused on the retina and, by changing shape, it adjusts …

Lanosterol reverses protein aggregation in cataracts

L Zhao, XJ Chen, J Zhu, YB **, X Yang, LD Hu… - Nature, 2015 - nature.com
The human lens is comprised largely of crystallin proteins assembled into a highly ordered,
interactive macro-structure essential for lens transparency and refractive index. Any …

Current trends in the pharmacotherapy of cataracts

SH Heruye, LN Maffofou Nkenyi, NU Singh… - Pharmaceuticals, 2020 - mdpi.com
Cataracts, one of the leading causes of preventable blindness worldwide, refers to lens
degradation that is characterized by clouding, with consequent blurry vision. As life …

Recent progress and research trend of anti-cataract pharmacology therapy: a bibliometric analysis and literature review

A Lu, P Duan, J **e, H Gao, M Chen, Y Gong… - European Journal of …, 2022 - Elsevier
Cataract is the leading cause of blindness worldwide. Cataract phacoemulsification
combined with intraocular lens implantation causes great burden to global healthcare …

Drug delivery to the lens for the management of cataracts

TR Thrimawithana, ID Rupenthal, SS Räsch… - Advanced drug delivery …, 2018 - Elsevier
Cataracts are one of the most prevalent diseases of the lens, affecting its transparency and
are the leading cause of reversible blindness in the world. The clarity of the lens is essential …

Breaking barriers: Nanomedicine-based drug delivery for cataract treatment

Y Chen, Z Ye, H Chen, Z Li - International Journal of Nanomedicine, 2024 - Taylor & Francis
Cataract is a leading cause of blindness globally, and its surgical treatment poses a
significant burden on global healthcare. Pharmacologic therapies, including antioxidants …

Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats

Y Maddirala, S Tobwala, H Karacal, N Ercal - BMC ophthalmology, 2017 - Springer
Background The present study sought to evaluate the efficacy of N-acetylcysteine amide
(NACA) eye drops in reversing the cataract formation induced by sodium selenite in male …

Neuroprotection in glaucoma: Old and new promising treatments

D Rusciano, S Pezzino, MG Mutolo… - Advances in …, 2017 - Wiley Online Library
Glaucoma is a major global cause of blindness, but the molecular mechanisms responsible
for the neurodegenerative damage are not clear. Undoubtedly, the high intraocular pressure …

Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: An in vitro study using isolated …

R Manikandan, R Thiagarajan, S Beulaja… - Chemico-biological …, 2009 - Elsevier
The aim of this study was to investigate whether curcumin and aminoguanidine (AG) prevent
selenium-induced cataractogenesis in vitro. On postpartum day 8, transparent isolated lens …