Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

I Akhlaghipour, AR Bina, MR Mogharrabi, A Fanoodi… - Human Genomics, 2022 - Springer
Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and
organs, including eyes, kidneys, and cardiovascular system. According to the World Health …

Disentangling the coronavirus disease 2019 health disparities in African Americans: biological, environmental, and social factors

G Saini, MH Swahn, R Aneja - Open forum infectious diseases, 2021 - academic.oup.com
The stark racial disparities related to the coronavirus disease 2019 (COVID-19) pandemic in
the United States, wherein minority populations are disproportionately getting infected and …

The predisposition for type 2 diabetes Mellitus and metabolic syndrome

C Zenoaga-Barbăroșie, L Berca… - Balkan Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are diseases caused by
the interaction of genetic and non-genetic factors. Therefore, the aim of our study was to …

Association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with risk of hypertension among the Ethiopian population

TA Birhan, MD Molla, M Abdulkadir, KH Tesfa - PLoS One, 2022 - journals.plos.org
Introduction Although the pathophysiological mechanism of hypertension is not fully
elucidated yet, a large number of pieces of evidence have shown that genetic alterations in …

Associations of ACE gene insertion/deletion polymorphism, ACE activity, and ACE mRNA expression with hypertension in a Chinese population

Q He, C Fan, M Yu, G Wallar, ZF Zhang, L Wang… - PLoS …, 2013 - journals.plos.org
Background The present study was designed to explore the association of angiotensin
converting enzyme (ACE) gene insertion/deletion (I/D, rs4646994) polymorphism, plasma …

Effects of angiotensin converting enzyme gene polymorphism on hypertension in Africa: A meta-analysis and systematic review

HG Mengesha, P Petrucka, C Spence, TB Tafesse - PloS one, 2019 - journals.plos.org
Background Hypertension is dramatically increasing in Africa with evidence of increased
severity and resistance to treatment. Although angiotensin converting enzyme gene …

Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19

S Shafiee, L Cegolon, M Khafaei, N Gholami… - Cancer cell …, 2021 - Springer
Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin
convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as …

Genetic factors contributing to hypertension in African‐based populations: A systematic review and meta‐analysis

YY Yako, EV Balti, TE Matsha, A Dzudie… - The Journal of …, 2018 - Wiley Online Library
In a systematic review, the authors explored genetic association studies of essential
hypertension in African populations. Studies reporting on the association of polymorphism …

Renin-angiotensin system gene variants and risk of early-and late-onset preeclampsia: A single center case-control study

LM Procopciuc, G Nemeti, E Buzdugan, M Iancu… - Pregnancy …, 2019 - Elsevier
Background Changes in the renin-angiotensin-aldosterone system's (RAAS) activity due to
different genetic variations could represent risk factors for the onset of preeclampsia …

Angiotensin-converting enzyme gene I/D polymorphism increases the susceptibility to hypertension and additive diseases: A study on North Indian patients

M Singh, AK Singh, S Singh, P Pandey… - Clinical and …, 2016 - Taylor & Francis
Angiotensin-converting enzyme (ACE) is the key enzyme of the renin angiotensin system
(RAS) which maintains the blood pressure homeostasis in our body. The association of the …